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Pediatric infection and sepsis in five age subgroups: single-center registry
BACKGROUND: Sepsis is, worldwide, one of the leading causes of death among infants and children. Over the past two decades, mortality rates have declined due to advanced treatment options; however, the incidence of sepsis and septic shock is still on the rise in many hospital settings. The objective...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835161/ https://www.ncbi.nlm.nih.gov/pubmed/33108806 http://dx.doi.org/10.1007/s10354-020-00787-6 |
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author | Hermon, Michael M. Etmayr, Theresa Brandt, Jennifer Bettina Sadeghi, Kambis Burda, Gudrun Golej, Johann |
author_facet | Hermon, Michael M. Etmayr, Theresa Brandt, Jennifer Bettina Sadeghi, Kambis Burda, Gudrun Golej, Johann |
author_sort | Hermon, Michael M. |
collection | PubMed |
description | BACKGROUND: Sepsis is, worldwide, one of the leading causes of death among infants and children. Over the past two decades, mortality rates have declined due to advanced treatment options; however, the incidence of sepsis and septic shock is still on the rise in many hospital settings. The objective of this study was to evaluate the course of this disease in pediatric intensive care patients. METHODS: An evaluation of pediatric patients in the intensive care unit diagnosed with infections or sepsis between 2005 and 2015 was performed via a retrospective exploratory data analysis. RESULTS: During the observational period, 201 patients were diagnosed with infection or sepsis. The study population was divided into five age subgroups. The majority of patients were newborns, infants, and toddlers. Forty percent had sepsis; 6% had septic shock. Viral infection was the most prevalent (59%). The overall survival rate was 83%; newborns and adolescents had the lowest survival rates. CONCLUSION: With this registry, children divided into five age subgroups with infection or sepsis were evaluated and treatment strategies were examined. We have shown that our findings on children treated in our pediatric intensive care unit conform with current literature about pediatric sepsis. In addition to maintaining strict hygiene standards, optimal aspects of sepsis care should be stringently observed, such as the quick administration of empirical broad-spectrum antibiotics, initial adequate fluid resuscitation, and a reliable and frequent routine of source control. |
format | Online Article Text |
id | pubmed-7835161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Vienna |
record_format | MEDLINE/PubMed |
spelling | pubmed-78351612021-01-29 Pediatric infection and sepsis in five age subgroups: single-center registry Hermon, Michael M. Etmayr, Theresa Brandt, Jennifer Bettina Sadeghi, Kambis Burda, Gudrun Golej, Johann Wien Med Wochenschr Original Article BACKGROUND: Sepsis is, worldwide, one of the leading causes of death among infants and children. Over the past two decades, mortality rates have declined due to advanced treatment options; however, the incidence of sepsis and septic shock is still on the rise in many hospital settings. The objective of this study was to evaluate the course of this disease in pediatric intensive care patients. METHODS: An evaluation of pediatric patients in the intensive care unit diagnosed with infections or sepsis between 2005 and 2015 was performed via a retrospective exploratory data analysis. RESULTS: During the observational period, 201 patients were diagnosed with infection or sepsis. The study population was divided into five age subgroups. The majority of patients were newborns, infants, and toddlers. Forty percent had sepsis; 6% had septic shock. Viral infection was the most prevalent (59%). The overall survival rate was 83%; newborns and adolescents had the lowest survival rates. CONCLUSION: With this registry, children divided into five age subgroups with infection or sepsis were evaluated and treatment strategies were examined. We have shown that our findings on children treated in our pediatric intensive care unit conform with current literature about pediatric sepsis. In addition to maintaining strict hygiene standards, optimal aspects of sepsis care should be stringently observed, such as the quick administration of empirical broad-spectrum antibiotics, initial adequate fluid resuscitation, and a reliable and frequent routine of source control. Springer Vienna 2020-10-27 2021 /pmc/articles/PMC7835161/ /pubmed/33108806 http://dx.doi.org/10.1007/s10354-020-00787-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Original Article Hermon, Michael M. Etmayr, Theresa Brandt, Jennifer Bettina Sadeghi, Kambis Burda, Gudrun Golej, Johann Pediatric infection and sepsis in five age subgroups: single-center registry |
title | Pediatric infection and sepsis in five age subgroups: single-center registry |
title_full | Pediatric infection and sepsis in five age subgroups: single-center registry |
title_fullStr | Pediatric infection and sepsis in five age subgroups: single-center registry |
title_full_unstemmed | Pediatric infection and sepsis in five age subgroups: single-center registry |
title_short | Pediatric infection and sepsis in five age subgroups: single-center registry |
title_sort | pediatric infection and sepsis in five age subgroups: single-center registry |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835161/ https://www.ncbi.nlm.nih.gov/pubmed/33108806 http://dx.doi.org/10.1007/s10354-020-00787-6 |
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