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Clinical validation of the novel HDAC6 radiotracer [(18)F]EKZ-001 in the human brain

PURPOSE: Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that modulates intracellular transport and protein quality control. Inhibition of HDAC6 deacetylase activity has shown beneficial effects in disease models, including Alzheimer’s disease and amyotrophic lateral sclerosis. This first-in-h...

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Detalles Bibliográficos
Autores principales:	Koole, Michel, Van Weehaeghe, Donatienne, Serdons, Kim, Herbots, Marissa, Cawthorne, Christopher, Celen, Sofie, Schroeder, Frederick A., Hooker, Jacob M., Bormans, Guy, de Hoon, Jan, Kranz, Janice E., Van Laere, Koen, Gilbert, Tonya M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835181/ https://www.ncbi.nlm.nih.gov/pubmed/32638097 http://dx.doi.org/10.1007/s00259-020-04891-y

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