Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features

In contrast to primary colorectal cancer (CRC) little is known about the genomic landscape of metastasized CRC. Here we present whole genome sequencing data of metastases of 429 CRC patients participating in the pan-cancer CPCT-02 study (NCT01855477). Unsupervised clustering using mutational signatu...

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Detalles Bibliográficos
Autores principales: Mendelaar, Pauline A. J., Smid, Marcel, van Riet, Job, Angus, Lindsay, Labots, Mariette, Steeghs, Neeltje, Hendriks, Mathijs P., Cirkel, Geert A., van Rooijen, Johan M., Ten Tije, Albert J., Lolkema, Martijn P., Cuppen, Edwin, Sleijfer, Stefan, Martens, John W. M., Wilting, Saskia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835235/
https://www.ncbi.nlm.nih.gov/pubmed/33495476
http://dx.doi.org/10.1038/s41467-020-20887-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835235/
https://www.ncbi.nlm.nih.gov/pubmed/33495476
http://dx.doi.org/10.1038/s41467-020-20887-6

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