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Increased [(18)F]FMISO accumulation under hypoxia by multidrug-resistant protein 1 inhibitors

BACKGROUND: [(18)F]Fluoromisonidazole ([(18)F]FMISO) is a PET imaging probe widely used for the detection of hypoxia. We previously reported that [(18)F]FMISO is metabolized to the glutathione conjugate of the reduced form in hypoxic cells. In addition, we found that the [(18)F]FMISO uptake level va...

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Detalles Bibliográficos
Autores principales:	Shimizu, Yoichi, Nakai, Yukihiro, Watanabe, Hiroyuki, Iikuni, Shimpei, Ono, Masahiro, Saji, Hideo, Kuge, Yuji, Saga, Tsuneo, Nakamoto, Yuji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Preliminary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835267/ https://www.ncbi.nlm.nih.gov/pubmed/33492449 http://dx.doi.org/10.1186/s13550-021-00752-3

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