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Cross-country evidence on the association between contact tracing and COVID-19 case fatality rates

The coronavirus disease (COVID-19) outbreak has killed over a million people since its emergence in late 2019. However, there has been substantial variability in the policies and intensity of diagnostic efforts between countries. In this paper, we quantitatively evaluate the association between nati...

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Autores principales: Yalaman, Abdullah, Basbug, Gokce, Elgin, Ceyhun, Galvani, Alison P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835347/
https://www.ncbi.nlm.nih.gov/pubmed/33495491
http://dx.doi.org/10.1038/s41598-020-78760-x
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author Yalaman, Abdullah
Basbug, Gokce
Elgin, Ceyhun
Galvani, Alison P.
author_facet Yalaman, Abdullah
Basbug, Gokce
Elgin, Ceyhun
Galvani, Alison P.
author_sort Yalaman, Abdullah
collection PubMed
description The coronavirus disease (COVID-19) outbreak has killed over a million people since its emergence in late 2019. However, there has been substantial variability in the policies and intensity of diagnostic efforts between countries. In this paper, we quantitatively evaluate the association between national contact tracing policies and case fatality rates of COVID-19 in 138 countries. Our regression analyses indicate that countries that implement comprehensive contact tracing have significantly lower case fatality rates. This association of contact tracing policy and case fatality rates is robust in our longitudinal regression models, even after controlling for the number of tests conducted and non-pharmaceutical control measures adopted by governments. Our results suggest that comprehensive contact tracing is instrumental not only to curtailing transmission but also to reducing case fatality rates. Contact tracing achieves the early detection and isolation of secondary cases which are particularly important given that the peak in infectiousness occurs during the presymptomatic phase. The early detection achieved by contact tracing accelerates the rate at which infected individuals receive medical care they need to maximize their chance of recovery. In addition, the combination of reduced transmission and more rapid recovery diminishes the burden on the healthcare system which in turn ensures that the resources remain available for individuals who do become infected.
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spelling pubmed-78353472021-01-27 Cross-country evidence on the association between contact tracing and COVID-19 case fatality rates Yalaman, Abdullah Basbug, Gokce Elgin, Ceyhun Galvani, Alison P. Sci Rep Article The coronavirus disease (COVID-19) outbreak has killed over a million people since its emergence in late 2019. However, there has been substantial variability in the policies and intensity of diagnostic efforts between countries. In this paper, we quantitatively evaluate the association between national contact tracing policies and case fatality rates of COVID-19 in 138 countries. Our regression analyses indicate that countries that implement comprehensive contact tracing have significantly lower case fatality rates. This association of contact tracing policy and case fatality rates is robust in our longitudinal regression models, even after controlling for the number of tests conducted and non-pharmaceutical control measures adopted by governments. Our results suggest that comprehensive contact tracing is instrumental not only to curtailing transmission but also to reducing case fatality rates. Contact tracing achieves the early detection and isolation of secondary cases which are particularly important given that the peak in infectiousness occurs during the presymptomatic phase. The early detection achieved by contact tracing accelerates the rate at which infected individuals receive medical care they need to maximize their chance of recovery. In addition, the combination of reduced transmission and more rapid recovery diminishes the burden on the healthcare system which in turn ensures that the resources remain available for individuals who do become infected. Nature Publishing Group UK 2021-01-25 /pmc/articles/PMC7835347/ /pubmed/33495491 http://dx.doi.org/10.1038/s41598-020-78760-x Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yalaman, Abdullah
Basbug, Gokce
Elgin, Ceyhun
Galvani, Alison P.
Cross-country evidence on the association between contact tracing and COVID-19 case fatality rates
title Cross-country evidence on the association between contact tracing and COVID-19 case fatality rates
title_full Cross-country evidence on the association between contact tracing and COVID-19 case fatality rates
title_fullStr Cross-country evidence on the association between contact tracing and COVID-19 case fatality rates
title_full_unstemmed Cross-country evidence on the association between contact tracing and COVID-19 case fatality rates
title_short Cross-country evidence on the association between contact tracing and COVID-19 case fatality rates
title_sort cross-country evidence on the association between contact tracing and covid-19 case fatality rates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835347/
https://www.ncbi.nlm.nih.gov/pubmed/33495491
http://dx.doi.org/10.1038/s41598-020-78760-x
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