The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine

Bacillus Calmette–Guérin (BCG), the only vaccine proven to be effective against tuberculosis (TB), is the most commonly used vaccine globally. In addition to its effects on mycobacterial diseases, an increasing amount of epidemiological and experimental evidence accumulated since its introduction in...

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Detalles Bibliográficos
Autores principales: Li, Junli, Zhan, Lingjun, Qin, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835355/
https://www.ncbi.nlm.nih.gov/pubmed/33495451
http://dx.doi.org/10.1038/s41541-020-00278-0
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author Li, Junli
Zhan, Lingjun
Qin, Chuan
author_facet Li, Junli
Zhan, Lingjun
Qin, Chuan
author_sort Li, Junli
collection PubMed
description Bacillus Calmette–Guérin (BCG), the only vaccine proven to be effective against tuberculosis (TB), is the most commonly used vaccine globally. In addition to its effects on mycobacterial diseases, an increasing amount of epidemiological and experimental evidence accumulated since its introduction in 1921 has shown that BCG also exerts non-specific effects against a number of diseases, such as non-mycobacterial infections, allergies and certain malignancies. Recent Corona Virus Disease 2019 (COVID-19) outbreak has put BCG, a classic vaccine with significant non-specific protection, into the spotlight again. This literature review briefly covers the diverse facets of BCG vaccine, providing new perspectives in terms of specific and non-specific protection mechanisms of this old, multifaceted, and controversial vaccine.
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spelling pubmed-78353552021-01-29 The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine Li, Junli Zhan, Lingjun Qin, Chuan NPJ Vaccines Review Article Bacillus Calmette–Guérin (BCG), the only vaccine proven to be effective against tuberculosis (TB), is the most commonly used vaccine globally. In addition to its effects on mycobacterial diseases, an increasing amount of epidemiological and experimental evidence accumulated since its introduction in 1921 has shown that BCG also exerts non-specific effects against a number of diseases, such as non-mycobacterial infections, allergies and certain malignancies. Recent Corona Virus Disease 2019 (COVID-19) outbreak has put BCG, a classic vaccine with significant non-specific protection, into the spotlight again. This literature review briefly covers the diverse facets of BCG vaccine, providing new perspectives in terms of specific and non-specific protection mechanisms of this old, multifaceted, and controversial vaccine. Nature Publishing Group UK 2021-01-25 /pmc/articles/PMC7835355/ /pubmed/33495451 http://dx.doi.org/10.1038/s41541-020-00278-0 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Li, Junli
Zhan, Lingjun
Qin, Chuan
The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
title The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
title_full The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
title_fullStr The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
title_full_unstemmed The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
title_short The double-sided effects of Mycobacterium Bovis bacillus Calmette–Guérin vaccine
title_sort double-sided effects of mycobacterium bovis bacillus calmette–guérin vaccine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835355/
https://www.ncbi.nlm.nih.gov/pubmed/33495451
http://dx.doi.org/10.1038/s41541-020-00278-0
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