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A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF
We have recently described the development of a series of small-molecule inhibitors of human tumour necrosis factor (TNF) that stabilise an open, asymmetric, signalling-deficient form of the soluble TNF trimer. Here, we describe the generation, characterisation, and utility of a monoclonal antibody...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835358/ https://www.ncbi.nlm.nih.gov/pubmed/33495445 http://dx.doi.org/10.1038/s41467-020-20825-6 |