A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF

We have recently described the development of a series of small-molecule inhibitors of human tumour necrosis factor (TNF) that stabilise an open, asymmetric, signalling-deficient form of the soluble TNF trimer. Here, we describe the generation, characterisation, and utility of a monoclonal antibody...

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Detalles Bibliográficos
Autores principales: Lightwood, Daniel J., Munro, Rebecca J., Porter, John, McMillan, David, Carrington, Bruce, Turner, Alison, Scott-Tucker, Anthony, Hickford, Elizabeth S., Schmidt, Antje, Fox, David, Maloney, Alison, Ceska, Tom, Bourne, Tim, O’Connell, James, Lawson, Alastair D. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835358/
https://www.ncbi.nlm.nih.gov/pubmed/33495445
http://dx.doi.org/10.1038/s41467-020-20825-6

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