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Bioinspired Modifications of PEEK Implants for Bone Tissue Engineering

In recent years, polyetheretherketone (PEEK) has been increasingly employed as an implant material in clinical applications. Although PEEK is biocompatible, chemically stable, and radiolucent and has an elastic modulus similar to that of natural bone, it suffers from poor integration with surroundin...

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Autores principales: Gu, Xinming, Sun, Xiaolin, Sun, Yue, Wang, Jia, Liu, Yiping, Yu, Kaixuan, Wang, Yao, Zhou, Yanmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835420/
https://www.ncbi.nlm.nih.gov/pubmed/33511108
http://dx.doi.org/10.3389/fbioe.2020.631616
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author Gu, Xinming
Sun, Xiaolin
Sun, Yue
Wang, Jia
Liu, Yiping
Yu, Kaixuan
Wang, Yao
Zhou, Yanmin
author_facet Gu, Xinming
Sun, Xiaolin
Sun, Yue
Wang, Jia
Liu, Yiping
Yu, Kaixuan
Wang, Yao
Zhou, Yanmin
author_sort Gu, Xinming
collection PubMed
description In recent years, polyetheretherketone (PEEK) has been increasingly employed as an implant material in clinical applications. Although PEEK is biocompatible, chemically stable, and radiolucent and has an elastic modulus similar to that of natural bone, it suffers from poor integration with surrounding bone tissue after implantation. To improve the bioactivity of PEEK, numerous strategies for functionalizing the PEEK surface and changing the PEEK structure have been proposed. Inspired by the components, structure, and function of bone tissue, this review discusses strategies to enhance the biocompatibility of PEEK implants and provides direction for fabricating multifunctional implants in the future.
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spelling pubmed-78354202021-01-27 Bioinspired Modifications of PEEK Implants for Bone Tissue Engineering Gu, Xinming Sun, Xiaolin Sun, Yue Wang, Jia Liu, Yiping Yu, Kaixuan Wang, Yao Zhou, Yanmin Front Bioeng Biotechnol Bioengineering and Biotechnology In recent years, polyetheretherketone (PEEK) has been increasingly employed as an implant material in clinical applications. Although PEEK is biocompatible, chemically stable, and radiolucent and has an elastic modulus similar to that of natural bone, it suffers from poor integration with surrounding bone tissue after implantation. To improve the bioactivity of PEEK, numerous strategies for functionalizing the PEEK surface and changing the PEEK structure have been proposed. Inspired by the components, structure, and function of bone tissue, this review discusses strategies to enhance the biocompatibility of PEEK implants and provides direction for fabricating multifunctional implants in the future. Frontiers Media S.A. 2021-01-12 /pmc/articles/PMC7835420/ /pubmed/33511108 http://dx.doi.org/10.3389/fbioe.2020.631616 Text en Copyright © 2021 Gu, Sun, Sun, Wang, Liu, Yu, Wang and Zhou. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Gu, Xinming
Sun, Xiaolin
Sun, Yue
Wang, Jia
Liu, Yiping
Yu, Kaixuan
Wang, Yao
Zhou, Yanmin
Bioinspired Modifications of PEEK Implants for Bone Tissue Engineering
title Bioinspired Modifications of PEEK Implants for Bone Tissue Engineering
title_full Bioinspired Modifications of PEEK Implants for Bone Tissue Engineering
title_fullStr Bioinspired Modifications of PEEK Implants for Bone Tissue Engineering
title_full_unstemmed Bioinspired Modifications of PEEK Implants for Bone Tissue Engineering
title_short Bioinspired Modifications of PEEK Implants for Bone Tissue Engineering
title_sort bioinspired modifications of peek implants for bone tissue engineering
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835420/
https://www.ncbi.nlm.nih.gov/pubmed/33511108
http://dx.doi.org/10.3389/fbioe.2020.631616
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