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Metabolism of Amino Acids in Cancer
Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism of amino acids are aberrantly upregulated in many cancers that display addiction to particular amino acids. Amino acids facilitate the survival and proliferation of cancer cells under genotoxic,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835483/ https://www.ncbi.nlm.nih.gov/pubmed/33511116 http://dx.doi.org/10.3389/fcell.2020.603837 |
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author | Wei, Zhen Liu, Xiaoyi Cheng, Chunming Yu, Wei Yi, Ping |
author_facet | Wei, Zhen Liu, Xiaoyi Cheng, Chunming Yu, Wei Yi, Ping |
author_sort | Wei, Zhen |
collection | PubMed |
description | Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism of amino acids are aberrantly upregulated in many cancers that display addiction to particular amino acids. Amino acids facilitate the survival and proliferation of cancer cells under genotoxic, oxidative, and nutritional stress. Thus, targeting amino acid metabolism is becoming a potential therapeutic strategy for cancer patients. In this review, we will systematically summarize the recent progress of amino acid metabolism in malignancy and discuss their interconnection with mammalian target of rapamycin complex 1 (mTORC1) signaling, epigenetic modification, tumor growth and immunity, and ferroptosis. Finally, we will highlight the potential therapeutic applications. |
format | Online Article Text |
id | pubmed-7835483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78354832021-01-27 Metabolism of Amino Acids in Cancer Wei, Zhen Liu, Xiaoyi Cheng, Chunming Yu, Wei Yi, Ping Front Cell Dev Biol Cell and Developmental Biology Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism of amino acids are aberrantly upregulated in many cancers that display addiction to particular amino acids. Amino acids facilitate the survival and proliferation of cancer cells under genotoxic, oxidative, and nutritional stress. Thus, targeting amino acid metabolism is becoming a potential therapeutic strategy for cancer patients. In this review, we will systematically summarize the recent progress of amino acid metabolism in malignancy and discuss their interconnection with mammalian target of rapamycin complex 1 (mTORC1) signaling, epigenetic modification, tumor growth and immunity, and ferroptosis. Finally, we will highlight the potential therapeutic applications. Frontiers Media S.A. 2021-01-12 /pmc/articles/PMC7835483/ /pubmed/33511116 http://dx.doi.org/10.3389/fcell.2020.603837 Text en Copyright © 2021 Wei, Liu, Cheng, Yu and Yi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Wei, Zhen Liu, Xiaoyi Cheng, Chunming Yu, Wei Yi, Ping Metabolism of Amino Acids in Cancer |
title | Metabolism of Amino Acids in Cancer |
title_full | Metabolism of Amino Acids in Cancer |
title_fullStr | Metabolism of Amino Acids in Cancer |
title_full_unstemmed | Metabolism of Amino Acids in Cancer |
title_short | Metabolism of Amino Acids in Cancer |
title_sort | metabolism of amino acids in cancer |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835483/ https://www.ncbi.nlm.nih.gov/pubmed/33511116 http://dx.doi.org/10.3389/fcell.2020.603837 |
work_keys_str_mv | AT weizhen metabolismofaminoacidsincancer AT liuxiaoyi metabolismofaminoacidsincancer AT chengchunming metabolismofaminoacidsincancer AT yuwei metabolismofaminoacidsincancer AT yiping metabolismofaminoacidsincancer |