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C-Terminal Peptide Modifications Reveal Direct and Indirect Roles of Hedgehog Morphogen Cholesteroylation

Hedgehog (Hh) morphogens are involved in embryonic development and stem cell biology and, if misregulated, can contribute to cancer. One important post-translational modification with profound impact on Hh biofunction is its C-terminal cholesteroylation during biosynthesis. The current hypothesis is...

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Detalles Bibliográficos
Autores principales:	Manikowski, Dominique, Kastl, Philipp, Schürmann, Sabine, Ehring, Kristina, Steffes, Georg, Jakobs, Petra, Grobe, Kay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835520/ https://www.ncbi.nlm.nih.gov/pubmed/33511123 http://dx.doi.org/10.3389/fcell.2020.615698

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