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Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy

Cardiac tissue requires a persistent production of energy in order to exert its pumping function. Therefore, the maintenance of this function relies on mitochondria that represent the “powerhouse” of all cardiac activities. Mitochondria being one of the key players for the proper functioning of the...

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Autores principales: Ramaccini, Daniela, Montoya-Uribe, Vanessa, Aan, Femke J., Modesti, Lorenzo, Potes, Yaiza, Wieckowski, Mariusz R., Krga, Irena, Glibetić, Marija, Pinton, Paolo, Giorgi, Carlotta, Matter, Michelle L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835522/
https://www.ncbi.nlm.nih.gov/pubmed/33511136
http://dx.doi.org/10.3389/fcell.2020.624216
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author Ramaccini, Daniela
Montoya-Uribe, Vanessa
Aan, Femke J.
Modesti, Lorenzo
Potes, Yaiza
Wieckowski, Mariusz R.
Krga, Irena
Glibetić, Marija
Pinton, Paolo
Giorgi, Carlotta
Matter, Michelle L.
author_facet Ramaccini, Daniela
Montoya-Uribe, Vanessa
Aan, Femke J.
Modesti, Lorenzo
Potes, Yaiza
Wieckowski, Mariusz R.
Krga, Irena
Glibetić, Marija
Pinton, Paolo
Giorgi, Carlotta
Matter, Michelle L.
author_sort Ramaccini, Daniela
collection PubMed
description Cardiac tissue requires a persistent production of energy in order to exert its pumping function. Therefore, the maintenance of this function relies on mitochondria that represent the “powerhouse” of all cardiac activities. Mitochondria being one of the key players for the proper functioning of the mammalian heart suggests continual regulation and organization. Mitochondria adapt to cellular energy demands via fusion-fission events and, as a proof-reading ability, undergo mitophagy in cases of abnormalities. Ca(2+) fluxes play a pivotal role in regulating all mitochondrial functions, including ATP production, metabolism, oxidative stress balance and apoptosis. Communication between mitochondria and others organelles, especially the sarcoplasmic reticulum is required for optimal function. Consequently, abnormal mitochondrial activity results in decreased energy production leading to pathological conditions. In this review, we will describe how mitochondrial function or dysfunction impacts cardiac activities and the development of dilated cardiomyopathy.
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spelling pubmed-78355222021-01-27 Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy Ramaccini, Daniela Montoya-Uribe, Vanessa Aan, Femke J. Modesti, Lorenzo Potes, Yaiza Wieckowski, Mariusz R. Krga, Irena Glibetić, Marija Pinton, Paolo Giorgi, Carlotta Matter, Michelle L. Front Cell Dev Biol Cell and Developmental Biology Cardiac tissue requires a persistent production of energy in order to exert its pumping function. Therefore, the maintenance of this function relies on mitochondria that represent the “powerhouse” of all cardiac activities. Mitochondria being one of the key players for the proper functioning of the mammalian heart suggests continual regulation and organization. Mitochondria adapt to cellular energy demands via fusion-fission events and, as a proof-reading ability, undergo mitophagy in cases of abnormalities. Ca(2+) fluxes play a pivotal role in regulating all mitochondrial functions, including ATP production, metabolism, oxidative stress balance and apoptosis. Communication between mitochondria and others organelles, especially the sarcoplasmic reticulum is required for optimal function. Consequently, abnormal mitochondrial activity results in decreased energy production leading to pathological conditions. In this review, we will describe how mitochondrial function or dysfunction impacts cardiac activities and the development of dilated cardiomyopathy. Frontiers Media S.A. 2021-01-12 /pmc/articles/PMC7835522/ /pubmed/33511136 http://dx.doi.org/10.3389/fcell.2020.624216 Text en Copyright © 2021 Ramaccini, Montoya-Uribe, Aan, Modesti, Potes, Wieckowski, Krga, Glibetić, Pinton, Giorgi and Matter. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ramaccini, Daniela
Montoya-Uribe, Vanessa
Aan, Femke J.
Modesti, Lorenzo
Potes, Yaiza
Wieckowski, Mariusz R.
Krga, Irena
Glibetić, Marija
Pinton, Paolo
Giorgi, Carlotta
Matter, Michelle L.
Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy
title Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy
title_full Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy
title_fullStr Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy
title_full_unstemmed Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy
title_short Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy
title_sort mitochondrial function and dysfunction in dilated cardiomyopathy
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835522/
https://www.ncbi.nlm.nih.gov/pubmed/33511136
http://dx.doi.org/10.3389/fcell.2020.624216
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