Influence of respiratory and inflammatory parameters preceding intubation on survival of patients with COVID-19 ARDS– A single centre retrospective analysis

It remains unclear if intubation and ventilation earlier in the disease course confers a survival advantage in acute respiratory distress syndrome. Our objective was to determine whether patients with COVID-19 who died following mechanical ventilation were more advanced in their disease compared to...

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Autores principales: Arulkumaran, N., Green, J., Khan, A., Bonnici, T., Longobardo, A., Singer, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835523/
https://www.ncbi.nlm.nih.gov/pubmed/33513551
http://dx.doi.org/10.1016/j.jcrc.2021.01.001
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author Arulkumaran, N.
Green, J.
Khan, A.
Bonnici, T.
Longobardo, A.
Singer, M.
author_facet Arulkumaran, N.
Green, J.
Khan, A.
Bonnici, T.
Longobardo, A.
Singer, M.
author_sort Arulkumaran, N.
collection PubMed
description It remains unclear if intubation and ventilation earlier in the disease course confers a survival advantage in acute respiratory distress syndrome. Our objective was to determine whether patients with COVID-19 who died following mechanical ventilation were more advanced in their disease compared to survivors. Forty-seven patients admitted directly to our centre received ventilation, of who 26 (57%) patients died. The rate of fall in SpO(2):FiO(2) ratio (p = 0.478) and increasing respiratory rate (p = 0.948) prior to IMV were similar between survivors and non-survivors. Our data support a trial of continuous positive airway pressure prior to IMV in patients with moderate-to-severe COVID-19 ARDS.
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spelling pubmed-78355232021-01-26 Influence of respiratory and inflammatory parameters preceding intubation on survival of patients with COVID-19 ARDS– A single centre retrospective analysis Arulkumaran, N. Green, J. Khan, A. Bonnici, T. Longobardo, A. Singer, M. J Crit Care Article It remains unclear if intubation and ventilation earlier in the disease course confers a survival advantage in acute respiratory distress syndrome. Our objective was to determine whether patients with COVID-19 who died following mechanical ventilation were more advanced in their disease compared to survivors. Forty-seven patients admitted directly to our centre received ventilation, of who 26 (57%) patients died. The rate of fall in SpO(2):FiO(2) ratio (p = 0.478) and increasing respiratory rate (p = 0.948) prior to IMV were similar between survivors and non-survivors. Our data support a trial of continuous positive airway pressure prior to IMV in patients with moderate-to-severe COVID-19 ARDS. Elsevier Inc. 2021-04 2021-01-08 /pmc/articles/PMC7835523/ /pubmed/33513551 http://dx.doi.org/10.1016/j.jcrc.2021.01.001 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Arulkumaran, N.
Green, J.
Khan, A.
Bonnici, T.
Longobardo, A.
Singer, M.
Influence of respiratory and inflammatory parameters preceding intubation on survival of patients with COVID-19 ARDS– A single centre retrospective analysis
title Influence of respiratory and inflammatory parameters preceding intubation on survival of patients with COVID-19 ARDS– A single centre retrospective analysis
title_full Influence of respiratory and inflammatory parameters preceding intubation on survival of patients with COVID-19 ARDS– A single centre retrospective analysis
title_fullStr Influence of respiratory and inflammatory parameters preceding intubation on survival of patients with COVID-19 ARDS– A single centre retrospective analysis
title_full_unstemmed Influence of respiratory and inflammatory parameters preceding intubation on survival of patients with COVID-19 ARDS– A single centre retrospective analysis
title_short Influence of respiratory and inflammatory parameters preceding intubation on survival of patients with COVID-19 ARDS– A single centre retrospective analysis
title_sort influence of respiratory and inflammatory parameters preceding intubation on survival of patients with covid-19 ards– a single centre retrospective analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835523/
https://www.ncbi.nlm.nih.gov/pubmed/33513551
http://dx.doi.org/10.1016/j.jcrc.2021.01.001
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