Current progress and challenges in the design and development of a successful COVID-19 vaccine

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still a worldwide concern, with little to no sign of a decreasing trend. There is a general consensus that normal life will be hampered until a safe and effective vaccine stra...

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Detalles Bibliográficos
Autores principales: Li, Tingting, Zhang, Tianying, Gu, Ying, Li, Shaowei, Xia, Ningshao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Publishing Services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835609/
http://dx.doi.org/10.1016/j.fmre.2021.01.011
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author Li, Tingting
Zhang, Tianying
Gu, Ying
Li, Shaowei
Xia, Ningshao
author_facet Li, Tingting
Zhang, Tianying
Gu, Ying
Li, Shaowei
Xia, Ningshao
author_sort Li, Tingting
collection PubMed
description The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still a worldwide concern, with little to no sign of a decreasing trend. There is a general consensus that normal life will be hampered until a safe and effective vaccine strategy is available and globally administered. Numerous countries have accelerated the clinical trials process for the development of a successful COVID-19 treatment, with over 200 candidates presently available for testing against SARS-CoV-2. Here, we provide an overview of the COVID-19 vaccine candidates currently in development, discuss the scientific and practical challenges associated with COVID-19 vaccine design, and share the potential strategies that could be exploited for vaccine design success.
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spelling pubmed-78356092021-01-26 Current progress and challenges in the design and development of a successful COVID-19 vaccine Li, Tingting Zhang, Tianying Gu, Ying Li, Shaowei Xia, Ningshao Fundamental Research Review The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still a worldwide concern, with little to no sign of a decreasing trend. There is a general consensus that normal life will be hampered until a safe and effective vaccine strategy is available and globally administered. Numerous countries have accelerated the clinical trials process for the development of a successful COVID-19 treatment, with over 200 candidates presently available for testing against SARS-CoV-2. Here, we provide an overview of the COVID-19 vaccine candidates currently in development, discuss the scientific and practical challenges associated with COVID-19 vaccine design, and share the potential strategies that could be exploited for vaccine design success. The Authors. Publishing Services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. 2021-03 2021-01-26 /pmc/articles/PMC7835609/ http://dx.doi.org/10.1016/j.fmre.2021.01.011 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Li, Tingting
Zhang, Tianying
Gu, Ying
Li, Shaowei
Xia, Ningshao
Current progress and challenges in the design and development of a successful COVID-19 vaccine
title Current progress and challenges in the design and development of a successful COVID-19 vaccine
title_full Current progress and challenges in the design and development of a successful COVID-19 vaccine
title_fullStr Current progress and challenges in the design and development of a successful COVID-19 vaccine
title_full_unstemmed Current progress and challenges in the design and development of a successful COVID-19 vaccine
title_short Current progress and challenges in the design and development of a successful COVID-19 vaccine
title_sort current progress and challenges in the design and development of a successful covid-19 vaccine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835609/
http://dx.doi.org/10.1016/j.fmre.2021.01.011
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