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Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells

Stem cells including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and adult stem cells (ASCs) are able to repair/replace damaged or degenerative tissues and improve functional recovery in experimental model and clinical trials. However, there are still many limitations and unr...

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Autores principales: Liu, Quan-Wen, Huang, Qi-Ming, Wu, Han-You, Zuo, Guo-Si-Lang, Gu, Hao-Cheng, Deng, Ke-Yu, Xin, Hong-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835733/
https://www.ncbi.nlm.nih.gov/pubmed/33478081
http://dx.doi.org/10.3390/ijms22020970
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author Liu, Quan-Wen
Huang, Qi-Ming
Wu, Han-You
Zuo, Guo-Si-Lang
Gu, Hao-Cheng
Deng, Ke-Yu
Xin, Hong-Bo
author_facet Liu, Quan-Wen
Huang, Qi-Ming
Wu, Han-You
Zuo, Guo-Si-Lang
Gu, Hao-Cheng
Deng, Ke-Yu
Xin, Hong-Bo
author_sort Liu, Quan-Wen
collection PubMed
description Stem cells including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and adult stem cells (ASCs) are able to repair/replace damaged or degenerative tissues and improve functional recovery in experimental model and clinical trials. However, there are still many limitations and unresolved problems regarding stem cell therapy in terms of ethical barriers, immune rejection, tumorigenicity, and cell sources. By reviewing recent literatures and our related works, human amnion-derived stem cells (hADSCs) including human amniotic mesenchymal stem cells (hAMSCs) and human amniotic epithelial stem cells (hAESCs) have shown considerable advantages over other stem cells. In this review, we first described the biological characteristics and advantages of hADSCs, especially for their high pluripotency and immunomodulatory effects. Then, we summarized the therapeutic applications and recent progresses of hADSCs in treating various diseases for preclinical research and clinical trials. In addition, the possible mechanisms and the challenges of hADSCs applications have been also discussed. Finally, we highlighted the properties of hADSCs as a promising source of stem cells for cell therapy and regenerative medicine and pointed out the perspectives for the directions of hADSCs applications clinically.
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spelling pubmed-78357332021-01-27 Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells Liu, Quan-Wen Huang, Qi-Ming Wu, Han-You Zuo, Guo-Si-Lang Gu, Hao-Cheng Deng, Ke-Yu Xin, Hong-Bo Int J Mol Sci Review Stem cells including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and adult stem cells (ASCs) are able to repair/replace damaged or degenerative tissues and improve functional recovery in experimental model and clinical trials. However, there are still many limitations and unresolved problems regarding stem cell therapy in terms of ethical barriers, immune rejection, tumorigenicity, and cell sources. By reviewing recent literatures and our related works, human amnion-derived stem cells (hADSCs) including human amniotic mesenchymal stem cells (hAMSCs) and human amniotic epithelial stem cells (hAESCs) have shown considerable advantages over other stem cells. In this review, we first described the biological characteristics and advantages of hADSCs, especially for their high pluripotency and immunomodulatory effects. Then, we summarized the therapeutic applications and recent progresses of hADSCs in treating various diseases for preclinical research and clinical trials. In addition, the possible mechanisms and the challenges of hADSCs applications have been also discussed. Finally, we highlighted the properties of hADSCs as a promising source of stem cells for cell therapy and regenerative medicine and pointed out the perspectives for the directions of hADSCs applications clinically. MDPI 2021-01-19 /pmc/articles/PMC7835733/ /pubmed/33478081 http://dx.doi.org/10.3390/ijms22020970 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Quan-Wen
Huang, Qi-Ming
Wu, Han-You
Zuo, Guo-Si-Lang
Gu, Hao-Cheng
Deng, Ke-Yu
Xin, Hong-Bo
Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells
title Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells
title_full Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells
title_fullStr Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells
title_full_unstemmed Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells
title_short Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells
title_sort characteristics and therapeutic potential of human amnion-derived stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835733/
https://www.ncbi.nlm.nih.gov/pubmed/33478081
http://dx.doi.org/10.3390/ijms22020970
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