Viscoelastic Hemostatic Assays and Platelet Function Testing in Patients with Atherosclerotic Vascular Diseases

Platelets play crucial role in acute vascular atherosclerotic diseases, including myocardial infarction and stroke. Additionally, platelet aggregation is a key target of antiplatelet agents, forming the keystone of pharmacotherapy of various atherosclerotic cardiovascular diseases. Thromboelastograp...

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Autores principales: Samoš, Matej, Škorňová, Ingrid, Bolek, Tomáš, Stančiaková, Lucia, Korpallová, Barbora, Galajda, Peter, Staško, Ján, Kubisz, Peter, Mokáň, Marián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835760/
https://www.ncbi.nlm.nih.gov/pubmed/33478051
http://dx.doi.org/10.3390/diagnostics11010143
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author Samoš, Matej
Škorňová, Ingrid
Bolek, Tomáš
Stančiaková, Lucia
Korpallová, Barbora
Galajda, Peter
Staško, Ján
Kubisz, Peter
Mokáň, Marián
author_facet Samoš, Matej
Škorňová, Ingrid
Bolek, Tomáš
Stančiaková, Lucia
Korpallová, Barbora
Galajda, Peter
Staško, Ján
Kubisz, Peter
Mokáň, Marián
author_sort Samoš, Matej
collection PubMed
description Platelets play crucial role in acute vascular atherosclerotic diseases, including myocardial infarction and stroke. Additionally, platelet aggregation is a key target of antiplatelet agents, forming the keystone of pharmacotherapy of various atherosclerotic cardiovascular diseases. Thromboelastography and thromboelastometry, representing currently available viscoelastic hemostatic assays (VHA), are designed as whole blood, real-time analyzers of clot formation and clot resolution. These assays could, in theory, overcome some limitations of currently available platelet function testing assays. This article reviews the current experience with the use of VHA for platelet function testing and for monitoring of the response to antiplatelet therapy.
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spelling pubmed-78357602021-01-27 Viscoelastic Hemostatic Assays and Platelet Function Testing in Patients with Atherosclerotic Vascular Diseases Samoš, Matej Škorňová, Ingrid Bolek, Tomáš Stančiaková, Lucia Korpallová, Barbora Galajda, Peter Staško, Ján Kubisz, Peter Mokáň, Marián Diagnostics (Basel) Review Platelets play crucial role in acute vascular atherosclerotic diseases, including myocardial infarction and stroke. Additionally, platelet aggregation is a key target of antiplatelet agents, forming the keystone of pharmacotherapy of various atherosclerotic cardiovascular diseases. Thromboelastography and thromboelastometry, representing currently available viscoelastic hemostatic assays (VHA), are designed as whole blood, real-time analyzers of clot formation and clot resolution. These assays could, in theory, overcome some limitations of currently available platelet function testing assays. This article reviews the current experience with the use of VHA for platelet function testing and for monitoring of the response to antiplatelet therapy. MDPI 2021-01-19 /pmc/articles/PMC7835760/ /pubmed/33478051 http://dx.doi.org/10.3390/diagnostics11010143 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Samoš, Matej
Škorňová, Ingrid
Bolek, Tomáš
Stančiaková, Lucia
Korpallová, Barbora
Galajda, Peter
Staško, Ján
Kubisz, Peter
Mokáň, Marián
Viscoelastic Hemostatic Assays and Platelet Function Testing in Patients with Atherosclerotic Vascular Diseases
title Viscoelastic Hemostatic Assays and Platelet Function Testing in Patients with Atherosclerotic Vascular Diseases
title_full Viscoelastic Hemostatic Assays and Platelet Function Testing in Patients with Atherosclerotic Vascular Diseases
title_fullStr Viscoelastic Hemostatic Assays and Platelet Function Testing in Patients with Atherosclerotic Vascular Diseases
title_full_unstemmed Viscoelastic Hemostatic Assays and Platelet Function Testing in Patients with Atherosclerotic Vascular Diseases
title_short Viscoelastic Hemostatic Assays and Platelet Function Testing in Patients with Atherosclerotic Vascular Diseases
title_sort viscoelastic hemostatic assays and platelet function testing in patients with atherosclerotic vascular diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835760/
https://www.ncbi.nlm.nih.gov/pubmed/33478051
http://dx.doi.org/10.3390/diagnostics11010143
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