The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury

A complete understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) physiopathology and related histopathologic lesions is necessary to improve treatment and outcome of coronavirus disease 2019 (COVID-19) patients. Many studies have focused on autopsy findings in COVID-19-relate...

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Autores principales: Zarrilli, Giovanni, Angerilli, Valentina, Businello, Gianluca, Sbaraglia, Marta, Traverso, Giulia, Fortarezza, Francesco, Rizzo, Stefania, Gaspari, Monica De, Basso, Cristina, Calabrese, Fiorella, Dei Tos, Angelo Paolo, Fassan, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835817/
https://www.ncbi.nlm.nih.gov/pubmed/33478107
http://dx.doi.org/10.3390/ijms22020974
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author Zarrilli, Giovanni
Angerilli, Valentina
Businello, Gianluca
Sbaraglia, Marta
Traverso, Giulia
Fortarezza, Francesco
Rizzo, Stefania
Gaspari, Monica De
Basso, Cristina
Calabrese, Fiorella
Dei Tos, Angelo Paolo
Fassan, Matteo
author_facet Zarrilli, Giovanni
Angerilli, Valentina
Businello, Gianluca
Sbaraglia, Marta
Traverso, Giulia
Fortarezza, Francesco
Rizzo, Stefania
Gaspari, Monica De
Basso, Cristina
Calabrese, Fiorella
Dei Tos, Angelo Paolo
Fassan, Matteo
author_sort Zarrilli, Giovanni
collection PubMed
description A complete understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) physiopathology and related histopathologic lesions is necessary to improve treatment and outcome of coronavirus disease 2019 (COVID-19) patients. Many studies have focused on autopsy findings in COVID-19-related deaths to try and define any possible specific pattern. Histopathologic alterations are principally found within lungs and blood vessels, and these abnormalities also seem to have the highest clinical impact. Nevertheless, many of the morphological data collected so far are non-specific, fickle, and possibly associated with other co-existing factors. The aim of this minireview is to describe the main histopathological features related to COVID-19 and the mechanism known as “cytokine storm”.
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spelling pubmed-78358172021-01-27 The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury Zarrilli, Giovanni Angerilli, Valentina Businello, Gianluca Sbaraglia, Marta Traverso, Giulia Fortarezza, Francesco Rizzo, Stefania Gaspari, Monica De Basso, Cristina Calabrese, Fiorella Dei Tos, Angelo Paolo Fassan, Matteo Int J Mol Sci Review A complete understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) physiopathology and related histopathologic lesions is necessary to improve treatment and outcome of coronavirus disease 2019 (COVID-19) patients. Many studies have focused on autopsy findings in COVID-19-related deaths to try and define any possible specific pattern. Histopathologic alterations are principally found within lungs and blood vessels, and these abnormalities also seem to have the highest clinical impact. Nevertheless, many of the morphological data collected so far are non-specific, fickle, and possibly associated with other co-existing factors. The aim of this minireview is to describe the main histopathological features related to COVID-19 and the mechanism known as “cytokine storm”. MDPI 2021-01-19 /pmc/articles/PMC7835817/ /pubmed/33478107 http://dx.doi.org/10.3390/ijms22020974 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zarrilli, Giovanni
Angerilli, Valentina
Businello, Gianluca
Sbaraglia, Marta
Traverso, Giulia
Fortarezza, Francesco
Rizzo, Stefania
Gaspari, Monica De
Basso, Cristina
Calabrese, Fiorella
Dei Tos, Angelo Paolo
Fassan, Matteo
The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury
title The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury
title_full The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury
title_fullStr The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury
title_full_unstemmed The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury
title_short The Immunopathological and Histological Landscape of COVID-19-Mediated Lung Injury
title_sort immunopathological and histological landscape of covid-19-mediated lung injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835817/
https://www.ncbi.nlm.nih.gov/pubmed/33478107
http://dx.doi.org/10.3390/ijms22020974
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