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The Association between Serum Vitamin D Levels and Helicobacter pylori Presence and Eradication

Background: The success of Helicobacter pylori (H. pylori) eradication depends on several host and treatment factors. Serum vitamin D levels may be associated with H. pylori infection and eradication rates. We investigated the association between vitamin D and H. pylori infection and eradication, us...

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Autores principales: Shafrir, Asher, Shauly-Aharonov, Michal, Katz, Lior H., Paltiel, Ora, Pickman, Yishai, Ackerman, Zvi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835846/
https://www.ncbi.nlm.nih.gov/pubmed/33478000
http://dx.doi.org/10.3390/nu13010278
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author Shafrir, Asher
Shauly-Aharonov, Michal
Katz, Lior H.
Paltiel, Ora
Pickman, Yishai
Ackerman, Zvi
author_facet Shafrir, Asher
Shauly-Aharonov, Michal
Katz, Lior H.
Paltiel, Ora
Pickman, Yishai
Ackerman, Zvi
author_sort Shafrir, Asher
collection PubMed
description Background: The success of Helicobacter pylori (H. pylori) eradication depends on several host and treatment factors. Serum vitamin D levels may be associated with H. pylori infection and eradication rates. We investigated the association between vitamin D and H. pylori infection and eradication, using a large electronic database based on medical records from a population-based health maintenance organization. Methods: Data regarding adults who underwent H. pylori testing and had vitamin D measurements within one month of H. pylori testing were collected. H. pylori infection was ascertained using urea breath or stool antigen tests. A negative H. pylori test following a positive result implied eradication. Multivariate regression models were constructed to assess associations between H. pylori infection, eradication, and vitamin D. Results: Among 150,483 members who underwent H. pylori testing from 2009 to 2018, 27,077 (18%) had vitamin D measurements. Vitamin D levels were inversely associated with H. pylori infection, p < 0.001. The odds of a positive H. pylori test were 31% higher among patients with vitamin D levels <20 ng/mL, compared with those with levels ≥20 ng/mL (OR 1.31, 99% CI 1.22–1.4, p < 0.001). Purchase of vitamin D supplements was associated with a negative subsequent H. pylori test (p < 0.001). Mean vitamin D levels were moderately higher in those with successful vs. failed H. pylori eradication (19.34 ± 9.55 vs. 18.64 ± 9.61, p < 0.001). Conclusions: Vitamin D levels are associated with H. pylori infection. Increased vitamin D levels are associated with successful H. pylori eradication. Vitamin D may have a role in H. pylori eradication.
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spelling pubmed-78358462021-01-27 The Association between Serum Vitamin D Levels and Helicobacter pylori Presence and Eradication Shafrir, Asher Shauly-Aharonov, Michal Katz, Lior H. Paltiel, Ora Pickman, Yishai Ackerman, Zvi Nutrients Article Background: The success of Helicobacter pylori (H. pylori) eradication depends on several host and treatment factors. Serum vitamin D levels may be associated with H. pylori infection and eradication rates. We investigated the association between vitamin D and H. pylori infection and eradication, using a large electronic database based on medical records from a population-based health maintenance organization. Methods: Data regarding adults who underwent H. pylori testing and had vitamin D measurements within one month of H. pylori testing were collected. H. pylori infection was ascertained using urea breath or stool antigen tests. A negative H. pylori test following a positive result implied eradication. Multivariate regression models were constructed to assess associations between H. pylori infection, eradication, and vitamin D. Results: Among 150,483 members who underwent H. pylori testing from 2009 to 2018, 27,077 (18%) had vitamin D measurements. Vitamin D levels were inversely associated with H. pylori infection, p < 0.001. The odds of a positive H. pylori test were 31% higher among patients with vitamin D levels <20 ng/mL, compared with those with levels ≥20 ng/mL (OR 1.31, 99% CI 1.22–1.4, p < 0.001). Purchase of vitamin D supplements was associated with a negative subsequent H. pylori test (p < 0.001). Mean vitamin D levels were moderately higher in those with successful vs. failed H. pylori eradication (19.34 ± 9.55 vs. 18.64 ± 9.61, p < 0.001). Conclusions: Vitamin D levels are associated with H. pylori infection. Increased vitamin D levels are associated with successful H. pylori eradication. Vitamin D may have a role in H. pylori eradication. MDPI 2021-01-19 /pmc/articles/PMC7835846/ /pubmed/33478000 http://dx.doi.org/10.3390/nu13010278 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shafrir, Asher
Shauly-Aharonov, Michal
Katz, Lior H.
Paltiel, Ora
Pickman, Yishai
Ackerman, Zvi
The Association between Serum Vitamin D Levels and Helicobacter pylori Presence and Eradication
title The Association between Serum Vitamin D Levels and Helicobacter pylori Presence and Eradication
title_full The Association between Serum Vitamin D Levels and Helicobacter pylori Presence and Eradication
title_fullStr The Association between Serum Vitamin D Levels and Helicobacter pylori Presence and Eradication
title_full_unstemmed The Association between Serum Vitamin D Levels and Helicobacter pylori Presence and Eradication
title_short The Association between Serum Vitamin D Levels and Helicobacter pylori Presence and Eradication
title_sort association between serum vitamin d levels and helicobacter pylori presence and eradication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835846/
https://www.ncbi.nlm.nih.gov/pubmed/33478000
http://dx.doi.org/10.3390/nu13010278
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