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Anionic Complex with Efficient Expression and Good Safety Profile for mRNA Delivery

We previously found that a complex comprising plasmid DNA (pDNA), polyethylenimine (PEI), and γ-polyglutamic acid (γ-PGA) had high transgene efficiency without cytotoxicity in vitro and in vivo. However, messenger RNA (mRNA) remains an attractive alternative to pDNA. In this study, we developed a sa...

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Detalles Bibliográficos
Autores principales:	Hamada, Eri, Kurosaki, Tomoaki, Hashizume, Junya, Harasawa, Hitomi, Nakagawa, Hiroo, Nakamura, Tadahiro, Kodama, Yukinobu, Sasaki, Hitoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835867/ https://www.ncbi.nlm.nih.gov/pubmed/33478077 http://dx.doi.org/10.3390/pharmaceutics13010126

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