A Selective Competitive Inhibitor of Aldehyde Dehydrogenase 1A3 Hinders Cancer Cell Growth, Invasiveness and Stemness In Vitro

SIMPLE SUMMARY: The aldehyde dehydrogenases enzymes (ALDHs) are promising drug targets in cancer therapy. ALDHs are members of an enzymatic superfamily composed by 19 isoforms involved in the oxidation of aldehydes, with a scavenger role. Among them, the isoform ALDH1A3 is a cancer biomarker since i...

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Detalles Bibliográficos
Autores principales: Gelardi, Edoardo L. M., Colombo, Giorgia, Picarazzi, Francesca, Ferraris, Davide M., Mangione, Andrea, Petrarolo, Giovanni, Aronica, Eleonora, Rizzi, Menico, Mori, Mattia, La Motta, Concettina, Garavaglia, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835878/
https://www.ncbi.nlm.nih.gov/pubmed/33478031
http://dx.doi.org/10.3390/cancers13020356

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