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Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy

Klotho was initially introduced as an antiaging molecule. Klotho deficiency significantly reduces lifespan, and its overexpression extends it and protects against various pathological phenotypes, especially renal disease. It was shown to regulate phosphate and calcium metabolism, protect against oxi...

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Detalles Bibliográficos
Autores principales: Typiak, Marlena, Piwkowska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835923/
https://www.ncbi.nlm.nih.gov/pubmed/33478014
http://dx.doi.org/10.3390/ijms22020956
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author Typiak, Marlena
Piwkowska, Agnieszka
author_facet Typiak, Marlena
Piwkowska, Agnieszka
author_sort Typiak, Marlena
collection PubMed
description Klotho was initially introduced as an antiaging molecule. Klotho deficiency significantly reduces lifespan, and its overexpression extends it and protects against various pathological phenotypes, especially renal disease. It was shown to regulate phosphate and calcium metabolism, protect against oxidative stress, downregulate apoptosis, and have antiinflammatory and antifibrotic properties. The course of diabetes mellitus and diabetic nephropathy resembles premature cellular senescence and causes the activation of various proinflammatory and profibrotic processes. Klotho was shown to exert many beneficial effects in these disorders. The expression of Klotho protein is downregulated in early stages of inflammation and diabetic nephropathy by proinflammatory factors. Therefore, its therapeutic effects are diminished in this disorder. Significantly lower urine levels of Klotho may serve as an early biomarker of renal involvement in diabetes mellitus. Recombinant Klotho administration and Klotho overexpression may have immunotherapeutic potential for the treatment of both diabetes and diabetic nephropathy. Therefore, the current manuscript aims to characterize immunopathologies occurring in diabetes and diabetic nephropathy, and tries to match them with antiinflammatory actions of Klotho. It also gives reasons for Klotho to be used in diagnostics and immunotherapy of these disorders.
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spelling pubmed-78359232021-01-27 Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy Typiak, Marlena Piwkowska, Agnieszka Int J Mol Sci Review Klotho was initially introduced as an antiaging molecule. Klotho deficiency significantly reduces lifespan, and its overexpression extends it and protects against various pathological phenotypes, especially renal disease. It was shown to regulate phosphate and calcium metabolism, protect against oxidative stress, downregulate apoptosis, and have antiinflammatory and antifibrotic properties. The course of diabetes mellitus and diabetic nephropathy resembles premature cellular senescence and causes the activation of various proinflammatory and profibrotic processes. Klotho was shown to exert many beneficial effects in these disorders. The expression of Klotho protein is downregulated in early stages of inflammation and diabetic nephropathy by proinflammatory factors. Therefore, its therapeutic effects are diminished in this disorder. Significantly lower urine levels of Klotho may serve as an early biomarker of renal involvement in diabetes mellitus. Recombinant Klotho administration and Klotho overexpression may have immunotherapeutic potential for the treatment of both diabetes and diabetic nephropathy. Therefore, the current manuscript aims to characterize immunopathologies occurring in diabetes and diabetic nephropathy, and tries to match them with antiinflammatory actions of Klotho. It also gives reasons for Klotho to be used in diagnostics and immunotherapy of these disorders. MDPI 2021-01-19 /pmc/articles/PMC7835923/ /pubmed/33478014 http://dx.doi.org/10.3390/ijms22020956 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Typiak, Marlena
Piwkowska, Agnieszka
Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy
title Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy
title_full Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy
title_fullStr Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy
title_full_unstemmed Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy
title_short Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy
title_sort antiinflammatory actions of klotho: implications for therapy of diabetic nephropathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835923/
https://www.ncbi.nlm.nih.gov/pubmed/33478014
http://dx.doi.org/10.3390/ijms22020956
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