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Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy
Klotho was initially introduced as an antiaging molecule. Klotho deficiency significantly reduces lifespan, and its overexpression extends it and protects against various pathological phenotypes, especially renal disease. It was shown to regulate phosphate and calcium metabolism, protect against oxi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835923/ https://www.ncbi.nlm.nih.gov/pubmed/33478014 http://dx.doi.org/10.3390/ijms22020956 |
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author | Typiak, Marlena Piwkowska, Agnieszka |
author_facet | Typiak, Marlena Piwkowska, Agnieszka |
author_sort | Typiak, Marlena |
collection | PubMed |
description | Klotho was initially introduced as an antiaging molecule. Klotho deficiency significantly reduces lifespan, and its overexpression extends it and protects against various pathological phenotypes, especially renal disease. It was shown to regulate phosphate and calcium metabolism, protect against oxidative stress, downregulate apoptosis, and have antiinflammatory and antifibrotic properties. The course of diabetes mellitus and diabetic nephropathy resembles premature cellular senescence and causes the activation of various proinflammatory and profibrotic processes. Klotho was shown to exert many beneficial effects in these disorders. The expression of Klotho protein is downregulated in early stages of inflammation and diabetic nephropathy by proinflammatory factors. Therefore, its therapeutic effects are diminished in this disorder. Significantly lower urine levels of Klotho may serve as an early biomarker of renal involvement in diabetes mellitus. Recombinant Klotho administration and Klotho overexpression may have immunotherapeutic potential for the treatment of both diabetes and diabetic nephropathy. Therefore, the current manuscript aims to characterize immunopathologies occurring in diabetes and diabetic nephropathy, and tries to match them with antiinflammatory actions of Klotho. It also gives reasons for Klotho to be used in diagnostics and immunotherapy of these disorders. |
format | Online Article Text |
id | pubmed-7835923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78359232021-01-27 Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy Typiak, Marlena Piwkowska, Agnieszka Int J Mol Sci Review Klotho was initially introduced as an antiaging molecule. Klotho deficiency significantly reduces lifespan, and its overexpression extends it and protects against various pathological phenotypes, especially renal disease. It was shown to regulate phosphate and calcium metabolism, protect against oxidative stress, downregulate apoptosis, and have antiinflammatory and antifibrotic properties. The course of diabetes mellitus and diabetic nephropathy resembles premature cellular senescence and causes the activation of various proinflammatory and profibrotic processes. Klotho was shown to exert many beneficial effects in these disorders. The expression of Klotho protein is downregulated in early stages of inflammation and diabetic nephropathy by proinflammatory factors. Therefore, its therapeutic effects are diminished in this disorder. Significantly lower urine levels of Klotho may serve as an early biomarker of renal involvement in diabetes mellitus. Recombinant Klotho administration and Klotho overexpression may have immunotherapeutic potential for the treatment of both diabetes and diabetic nephropathy. Therefore, the current manuscript aims to characterize immunopathologies occurring in diabetes and diabetic nephropathy, and tries to match them with antiinflammatory actions of Klotho. It also gives reasons for Klotho to be used in diagnostics and immunotherapy of these disorders. MDPI 2021-01-19 /pmc/articles/PMC7835923/ /pubmed/33478014 http://dx.doi.org/10.3390/ijms22020956 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Typiak, Marlena Piwkowska, Agnieszka Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy |
title | Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy |
title_full | Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy |
title_fullStr | Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy |
title_full_unstemmed | Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy |
title_short | Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy |
title_sort | antiinflammatory actions of klotho: implications for therapy of diabetic nephropathy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835923/ https://www.ncbi.nlm.nih.gov/pubmed/33478014 http://dx.doi.org/10.3390/ijms22020956 |
work_keys_str_mv | AT typiakmarlena antiinflammatoryactionsofklothoimplicationsfortherapyofdiabeticnephropathy AT piwkowskaagnieszka antiinflammatoryactionsofklothoimplicationsfortherapyofdiabeticnephropathy |