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Selective Inhibition of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases by the Phosphonate Analogs of Their 2-Oxo Acid Substrates

Phosphonate analogs of pyruvate and 2-oxoglutarate are established specific inhibitors of cognate 2-oxo acid dehydrogenases. The present work develops application of this class of compounds to specific in vivo inhibition of 2-oxoglutarate dehydrogenase (OGDH) and its isoenzyme, 2-oxoadipate dehydrog...

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Detalles Bibliográficos
Autores principales:	Artiukhov, Artem V., Kazantsev, Alexey V., Lukashev, Nikolay V., Bellinzoni, Marco, Bunik, Victoria I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835950/ https://www.ncbi.nlm.nih.gov/pubmed/33511099 http://dx.doi.org/10.3389/fchem.2020.596187

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