Nanomaterial Delivery Systems for mRNA Vaccines

The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the development of lipid nanoparticle delivery systems that not only efficiently express the mRNA-encoded immunogen after intramuscular injection, but also play roles as adjuvants and in vaccine reactogenicity. We pr...

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Autores principales: Buschmann, Michael D., Carrasco, Manuel J., Alishetty, Suman, Paige, Mikell, Alameh, Mohamad Gabriel, Weissman, Drew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836001/
https://www.ncbi.nlm.nih.gov/pubmed/33478109
http://dx.doi.org/10.3390/vaccines9010065
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author Buschmann, Michael D.
Carrasco, Manuel J.
Alishetty, Suman
Paige, Mikell
Alameh, Mohamad Gabriel
Weissman, Drew
author_facet Buschmann, Michael D.
Carrasco, Manuel J.
Alishetty, Suman
Paige, Mikell
Alameh, Mohamad Gabriel
Weissman, Drew
author_sort Buschmann, Michael D.
collection PubMed
description The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the development of lipid nanoparticle delivery systems that not only efficiently express the mRNA-encoded immunogen after intramuscular injection, but also play roles as adjuvants and in vaccine reactogenicity. We present an overview of mRNA delivery systems and then focus on the lipid nanoparticles used in the current SARS-CoV-2 vaccine clinical trials. The review concludes with an analysis of the determinants of the performance of lipid nanoparticles in mRNA vaccines.
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spelling pubmed-78360012021-01-27 Nanomaterial Delivery Systems for mRNA Vaccines Buschmann, Michael D. Carrasco, Manuel J. Alishetty, Suman Paige, Mikell Alameh, Mohamad Gabriel Weissman, Drew Vaccines (Basel) Review The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the development of lipid nanoparticle delivery systems that not only efficiently express the mRNA-encoded immunogen after intramuscular injection, but also play roles as adjuvants and in vaccine reactogenicity. We present an overview of mRNA delivery systems and then focus on the lipid nanoparticles used in the current SARS-CoV-2 vaccine clinical trials. The review concludes with an analysis of the determinants of the performance of lipid nanoparticles in mRNA vaccines. MDPI 2021-01-19 /pmc/articles/PMC7836001/ /pubmed/33478109 http://dx.doi.org/10.3390/vaccines9010065 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Buschmann, Michael D.
Carrasco, Manuel J.
Alishetty, Suman
Paige, Mikell
Alameh, Mohamad Gabriel
Weissman, Drew
Nanomaterial Delivery Systems for mRNA Vaccines
title Nanomaterial Delivery Systems for mRNA Vaccines
title_full Nanomaterial Delivery Systems for mRNA Vaccines
title_fullStr Nanomaterial Delivery Systems for mRNA Vaccines
title_full_unstemmed Nanomaterial Delivery Systems for mRNA Vaccines
title_short Nanomaterial Delivery Systems for mRNA Vaccines
title_sort nanomaterial delivery systems for mrna vaccines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836001/
https://www.ncbi.nlm.nih.gov/pubmed/33478109
http://dx.doi.org/10.3390/vaccines9010065
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