Assessments of the In Vitro and In Vivo Linker Stability and Catabolic Fate for the Ortho Hydroxy-Protected Aryl Sulfate Linker by Immuno-Affinity Capture Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometric Assay

Antibody–drug conjugate (ADC) linkers play an important role in determining the safety and efficacy of ADC. The Ortho Hydroxy-Protected Aryl Sulfate (OHPAS) linker is a newly developed linker in the form of a di-aryl sulfate structure consisting of phenolic payload and self-immolative group (SIG). I...

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Detalles Bibliográficos
Autores principales: Lee, Byeong ill, Park, Seo-jin, Park, Yuri, Shin, Seok-Ho, Choi, Jang-mi, Park, Min-jae, Lim, Jeong-hyeon, Kim, Sun Young, Lee, Hyangsook, Shin, Young G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836004/
https://www.ncbi.nlm.nih.gov/pubmed/33478046
http://dx.doi.org/10.3390/pharmaceutics13010125

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