Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ

Biological processes are regulated by intermolecular interactions and chemical modifications that do not affect protein levels, thus escaping detection in classical proteomic screens. We demonstrate here that a global protein structural readout based on limited proteolysis-mass spectrometry (LiP-MS)...

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Detalles Bibliográficos
Autores principales: Cappelletti, Valentina, Hauser, Thomas, Piazza, Ilaria, Pepelnjak, Monika, Malinovska, Liliana, Fuhrer, Tobias, Li, Yaozong, Dörig, Christian, Boersema, Paul, Gillet, Ludovic, Grossbach, Jan, Dugourd, Aurelien, Saez-Rodriguez, Julio, Beyer, Andreas, Zamboni, Nicola, Caflisch, Amedeo, de Souza, Natalie, Picotti, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Resource
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836100/
https://www.ncbi.nlm.nih.gov/pubmed/33357446
http://dx.doi.org/10.1016/j.cell.2020.12.021

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