Non-Invasive Strategies for Nose-to-Brain Drug Delivery

Intranasal drug administration is a promising method for delivering drugs directly to the brain. Animal studies have described pathways and potential brain targets, but nose-to-brain delivery and treatment efficacy in humans remains debated. We describe the proposed pathways and barriers for nose-to...

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Detalles Bibliográficos
Autores principales: Trevino, JT, Quispe, RC, Khan, F, Novak, V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836101/
https://www.ncbi.nlm.nih.gov/pubmed/33505777
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author Trevino, JT
Quispe, RC
Khan, F
Novak, V
author_facet Trevino, JT
Quispe, RC
Khan, F
Novak, V
author_sort Trevino, JT
collection PubMed
description Intranasal drug administration is a promising method for delivering drugs directly to the brain. Animal studies have described pathways and potential brain targets, but nose-to-brain delivery and treatment efficacy in humans remains debated. We describe the proposed pathways and barriers for nose-to-brain drug delivery in humans, drug properties that influence central nervous system delivery, clinically tested methods to enhance absorption, and the devices used in clinical trials. This review compiles the available evidence for nose-to-brain drug delivery in humans and summarizes the factors involved in nose-to-brain drug delivery.
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spelling pubmed-78361012021-01-26 Non-Invasive Strategies for Nose-to-Brain Drug Delivery Trevino, JT Quispe, RC Khan, F Novak, V J Clin Trials Article Intranasal drug administration is a promising method for delivering drugs directly to the brain. Animal studies have described pathways and potential brain targets, but nose-to-brain delivery and treatment efficacy in humans remains debated. We describe the proposed pathways and barriers for nose-to-brain drug delivery in humans, drug properties that influence central nervous system delivery, clinically tested methods to enhance absorption, and the devices used in clinical trials. This review compiles the available evidence for nose-to-brain drug delivery in humans and summarizes the factors involved in nose-to-brain drug delivery. 2020 2020-12-10 /pmc/articles/PMC7836101/ /pubmed/33505777 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Trevino, JT
Quispe, RC
Khan, F
Novak, V
Non-Invasive Strategies for Nose-to-Brain Drug Delivery
title Non-Invasive Strategies for Nose-to-Brain Drug Delivery
title_full Non-Invasive Strategies for Nose-to-Brain Drug Delivery
title_fullStr Non-Invasive Strategies for Nose-to-Brain Drug Delivery
title_full_unstemmed Non-Invasive Strategies for Nose-to-Brain Drug Delivery
title_short Non-Invasive Strategies for Nose-to-Brain Drug Delivery
title_sort non-invasive strategies for nose-to-brain drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836101/
https://www.ncbi.nlm.nih.gov/pubmed/33505777
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