Severe COVID-19 associated variants linked to chemokine receptor gene control in monocytes and macrophages

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Genome-wide association studies have identified 3p21.31 as the main risk locus for severe disease in COVID-19 patients, although underlying biological mechanisms remain elusive. We performed a comprehensive epigenomic dissection of the 3p21.31 locus, identifying a CTCF-dependent tissue-specific 3D r...

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Detalles Bibliográficos
Autores principales: Stikker, Bernard, Stik, Grégoire, Hendriks, Rudi W., Stadhouders, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836105/
https://www.ncbi.nlm.nih.gov/pubmed/33501435
http://dx.doi.org/10.1101/2021.01.22.427813
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