BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2

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SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted a targeted CRISPRi screen to uncover druggable pathways controlling Spike protein binding to human cells. We found that the protein BRD2 is required for ACE2 tra...

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Detalles Bibliográficos
Autores principales: Samelson, Avi J., Tran, Quang Dinh, Robinot, Rémy, Carrau, Lucia, Rezelj, Veronica V., Mac Kain, Alice, Chen, Merissa, Ramadoss, Gokul N., Guo, Xiaoyan, Lim, Shion A., Lui, Irene, Nunez, James, Rockwood, Sarah J., Wang, Jianhui, Liu, Na, Carlson-Stevermer, Jared, Oki, Jennifer, Maures, Travis, Holden, Kevin, Weissman, Jonathan S., Wells, James A., Conklin, Bruce R., TenOever, Benjamin R., Chakrabarti, Lisa A., Vignuzzi, Marco, Tian, Ruilin, Kampmann, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836110/
https://www.ncbi.nlm.nih.gov/pubmed/33501440
http://dx.doi.org/10.1101/2021.01.19.427194
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