SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseu...

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Detalles Bibliográficos
Autores principales: Wibmer, Constantinos Kurt, Ayres, Frances, Hermanus, Tandile, Madzivhandila, Mashudu, Kgagudi, Prudence, Oosthuysen, Brent, Lambson, Bronwen E., de Oliveira, Tulio, Vermeulen, Marion, van der Berg, Karin, Rossouw, Theresa, Boswell, Michael, Ueckermann, Veronica, Meiring, Susan, von Gottberg, Anne, Cohen, Cheryl, Morris, Lynn, Bhiman, Jinal N., Moore, Penny L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836116/
https://www.ncbi.nlm.nih.gov/pubmed/33501446
http://dx.doi.org/10.1101/2021.01.18.427166
Descripción
Sumario:SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.

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