Dexamethasone: Therapeutic potential, risks, and future projection during COVID-19 pandemic

The current outbreak of novel COVID-19 challenges the development of an efficient treatment plan as soon as possible. Several promising treatment options stand out as potential therapy of COVID-19, including plasma-derived drugs, monoclonal antibodies, antivirals, antimalarial, cell therapy, and cor...

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Detalles Bibliográficos
Autores principales: Noreen, Sobia, Maqbool, Irsah, Madni, Asadullah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836247/
https://www.ncbi.nlm.nih.gov/pubmed/33428898
http://dx.doi.org/10.1016/j.ejphar.2021.173854
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author Noreen, Sobia
Maqbool, Irsah
Madni, Asadullah
author_facet Noreen, Sobia
Maqbool, Irsah
Madni, Asadullah
author_sort Noreen, Sobia
collection PubMed
description The current outbreak of novel COVID-19 challenges the development of an efficient treatment plan as soon as possible. Several promising treatment options stand out as potential therapy of COVID-19, including plasma-derived drugs, monoclonal antibodies, antivirals, antimalarial, cell therapy, and corticosteroids. Dexamethasone an approved corticosteroid medication, acting as an anti-inflammatory and immunosuppressant agent. In the current pandemic, dexamethasone is declared a “major development” in the fight against COVID-19. Steroidal dexamethasone was presented as the recent advancement that significantly reduces the mortality rate among severe COVID-19 cases. This review summarizes the preliminary opinion about the dexamethasone outbreak, therapeutic potential, risks, and strategies during the COVID-19 pandemic.
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spelling pubmed-78362472021-01-26 Dexamethasone: Therapeutic potential, risks, and future projection during COVID-19 pandemic Noreen, Sobia Maqbool, Irsah Madni, Asadullah Eur J Pharmacol Review The current outbreak of novel COVID-19 challenges the development of an efficient treatment plan as soon as possible. Several promising treatment options stand out as potential therapy of COVID-19, including plasma-derived drugs, monoclonal antibodies, antivirals, antimalarial, cell therapy, and corticosteroids. Dexamethasone an approved corticosteroid medication, acting as an anti-inflammatory and immunosuppressant agent. In the current pandemic, dexamethasone is declared a “major development” in the fight against COVID-19. Steroidal dexamethasone was presented as the recent advancement that significantly reduces the mortality rate among severe COVID-19 cases. This review summarizes the preliminary opinion about the dexamethasone outbreak, therapeutic potential, risks, and strategies during the COVID-19 pandemic. Elsevier B.V. 2021-03-05 2021-01-08 /pmc/articles/PMC7836247/ /pubmed/33428898 http://dx.doi.org/10.1016/j.ejphar.2021.173854 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Noreen, Sobia
Maqbool, Irsah
Madni, Asadullah
Dexamethasone: Therapeutic potential, risks, and future projection during COVID-19 pandemic
title Dexamethasone: Therapeutic potential, risks, and future projection during COVID-19 pandemic
title_full Dexamethasone: Therapeutic potential, risks, and future projection during COVID-19 pandemic
title_fullStr Dexamethasone: Therapeutic potential, risks, and future projection during COVID-19 pandemic
title_full_unstemmed Dexamethasone: Therapeutic potential, risks, and future projection during COVID-19 pandemic
title_short Dexamethasone: Therapeutic potential, risks, and future projection during COVID-19 pandemic
title_sort dexamethasone: therapeutic potential, risks, and future projection during covid-19 pandemic
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836247/
https://www.ncbi.nlm.nih.gov/pubmed/33428898
http://dx.doi.org/10.1016/j.ejphar.2021.173854
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