Cell-free DNA tissues of origin by methylation profiling reveals significant cell, tissue, and organ-specific injury related to COVID-19 severity

BACKGROUND: Coronavirus disease 2019 (COVID-19) primarily affects the lungs, but evidence of systemic disease with multi-organ involvement is emerging. Here, we developed a blood test to broadly quantify cell-, tissue-, and organ-specific injury due to COVID-19. METHODS: Our test leverages genome-wi...

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Detalles Bibliográficos
Autores principales: Cheng, Alexandre Pellan, Cheng, Matthew Pellan, Gu, Wei, Sesing Lenz, Joan, Hsu, Elaine, Schurr, Erwin, Bourque, Guillaume, Bourgey, Mathieu, Ritz, Jerome, Marty, Francisco M., Chiu, Charles Y., Vinh, Donald C., De Vlaminck, Iwijn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Clinical and Translational Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836424/
https://www.ncbi.nlm.nih.gov/pubmed/33521749
http://dx.doi.org/10.1016/j.medj.2021.01.001

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