CRISPRi enables isoform-specific loss-of-function screens and identification of gastric cancer-specific isoform dependencies

INTRODUCTION: Genes contain multiple promoters that can drive the expression of various transcript isoforms. Although transcript isoforms from the same gene could have diverse and non-overlapping functions, current loss-of-function methodologies are not able to differentiate between isoform-specific...

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Detalles Bibliográficos
Autores principales: Davies, Rebecca, Liu, Ling, Taotao, Sheng, Tuano, Natasha, Chaturvedi, Richa, Huang, Kie Kyon, Itman, Catherine, Mandoli, Amit, Qamra, Aditi, Hu, Changyuan, Powell, David, Daly, Roger J., Tan, Patrick, Rosenbluh, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836456/
https://www.ncbi.nlm.nih.gov/pubmed/33499898
http://dx.doi.org/10.1186/s13059-021-02266-6

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