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De novo adult acute myeloid leukemia with two new mutations in juxtatransmembrane domain of the FLT3 gene: a case report

BACKGROUND: Approximately 30% of adult acute myeloid leukemia (AML) acquire within fms-like tyrosine kinase 3 gene (FLT3) internal tandem duplications (FLT3/ITDs) in their juxtamembrane domain (JMD). FLT3/ITDs range in size from three to hundreds of nucleotides, and confer an adverse prognosis. Stud...

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Detalles Bibliográficos
Autores principales:	Alarbeed, Ismael F., Wafa, Abdulsamad, Moassass, Faten, Al-Halabi, Bassel, Al-Achkar, Walid, Liehr, Thomas, Aboukhamis, Imad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836474/ https://www.ncbi.nlm.nih.gov/pubmed/33494808 http://dx.doi.org/10.1186/s13256-020-02587-3

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