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Efficiency of non-invasive prenatal screening in pregnant women at advanced maternal age

BACKGROUND: Non-invasive prenatal screening (NIPS) is widely used as the alternative choice for pregnant women at high-risk of fetal aneuploidy. However, whether NIPS has a good detective efficiency for pregnant women at advanced maternal age (AMA) has not been fully studied especially in Chinese wo...

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Autores principales: Zhu, Hui, Jin, Xiaoxiao, Xu, Yuqing, Zhang, Weihua, Liu, Xiaodan, Jin, Jinglei, Qian, Yeqing, Dong, Minyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836475/
https://www.ncbi.nlm.nih.gov/pubmed/33499806
http://dx.doi.org/10.1186/s12884-021-03570-6
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author Zhu, Hui
Jin, Xiaoxiao
Xu, Yuqing
Zhang, Weihua
Liu, Xiaodan
Jin, Jinglei
Qian, Yeqing
Dong, Minyue
author_facet Zhu, Hui
Jin, Xiaoxiao
Xu, Yuqing
Zhang, Weihua
Liu, Xiaodan
Jin, Jinglei
Qian, Yeqing
Dong, Minyue
author_sort Zhu, Hui
collection PubMed
description BACKGROUND: Non-invasive prenatal screening (NIPS) is widely used as the alternative choice for pregnant women at high-risk of fetal aneuploidy. However, whether NIPS has a good detective efficiency for pregnant women at advanced maternal age (AMA) has not been fully studied especially in Chinese women. METHODS: Twenty-nine thousand three hundred forty-three pregnant women at AMA with singleton pregnancy who received NIPS and followed-up were recruited. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), receiver operating characteristic (ROC) curves and the Youden Index for detecting fetal chromosomal aneuploidies were analyzed. The relationship between maternal age and common fetal chromosomal aneuploidy was observed. RESULTS: The sensitivity, specificity, PPV, NPV of NIPS for detecting fetal trisomy 21 were 99.11, 99.96, 90.98, and 100%, respectively. These same parameters for detecting fetal trisomy 18 were 100, 99.94, 67.92, and 100%, respectively. Finally, these parameters for detecting trisomy 13 were 100, 99.96, 27.78, and 100%, respectively. The prevalence of fetal trisomy 21 increased exponentially with maternal age. The high-risk percentage incidence rate of fetal trisomy 21 was significantly higher in the pregnant women at 37 years old or above than that in pregnant women at 35 to 37 years old. (Youden index = 37). CONCLUSION: It is indicated that NIPS is an effective prenatal screening method for pregnant women at AMA.
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spelling pubmed-78364752021-01-26 Efficiency of non-invasive prenatal screening in pregnant women at advanced maternal age Zhu, Hui Jin, Xiaoxiao Xu, Yuqing Zhang, Weihua Liu, Xiaodan Jin, Jinglei Qian, Yeqing Dong, Minyue BMC Pregnancy Childbirth Research Article BACKGROUND: Non-invasive prenatal screening (NIPS) is widely used as the alternative choice for pregnant women at high-risk of fetal aneuploidy. However, whether NIPS has a good detective efficiency for pregnant women at advanced maternal age (AMA) has not been fully studied especially in Chinese women. METHODS: Twenty-nine thousand three hundred forty-three pregnant women at AMA with singleton pregnancy who received NIPS and followed-up were recruited. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV), receiver operating characteristic (ROC) curves and the Youden Index for detecting fetal chromosomal aneuploidies were analyzed. The relationship between maternal age and common fetal chromosomal aneuploidy was observed. RESULTS: The sensitivity, specificity, PPV, NPV of NIPS for detecting fetal trisomy 21 were 99.11, 99.96, 90.98, and 100%, respectively. These same parameters for detecting fetal trisomy 18 were 100, 99.94, 67.92, and 100%, respectively. Finally, these parameters for detecting trisomy 13 were 100, 99.96, 27.78, and 100%, respectively. The prevalence of fetal trisomy 21 increased exponentially with maternal age. The high-risk percentage incidence rate of fetal trisomy 21 was significantly higher in the pregnant women at 37 years old or above than that in pregnant women at 35 to 37 years old. (Youden index = 37). CONCLUSION: It is indicated that NIPS is an effective prenatal screening method for pregnant women at AMA. BioMed Central 2021-01-26 /pmc/articles/PMC7836475/ /pubmed/33499806 http://dx.doi.org/10.1186/s12884-021-03570-6 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Zhu, Hui
Jin, Xiaoxiao
Xu, Yuqing
Zhang, Weihua
Liu, Xiaodan
Jin, Jinglei
Qian, Yeqing
Dong, Minyue
Efficiency of non-invasive prenatal screening in pregnant women at advanced maternal age
title Efficiency of non-invasive prenatal screening in pregnant women at advanced maternal age
title_full Efficiency of non-invasive prenatal screening in pregnant women at advanced maternal age
title_fullStr Efficiency of non-invasive prenatal screening in pregnant women at advanced maternal age
title_full_unstemmed Efficiency of non-invasive prenatal screening in pregnant women at advanced maternal age
title_short Efficiency of non-invasive prenatal screening in pregnant women at advanced maternal age
title_sort efficiency of non-invasive prenatal screening in pregnant women at advanced maternal age
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836475/
https://www.ncbi.nlm.nih.gov/pubmed/33499806
http://dx.doi.org/10.1186/s12884-021-03570-6
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