Computed optical spectra of SARS-CoV-2 proteins()

Treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19, may well be predicated on knowledge of the structures of protein of this virus. However, often these cannot be determined easily or quickly. Herein, we provide calculated circular dichroism (C...

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Detalles Bibliográficos
Autores principales: Li, Zhuo, Hirst, Jonathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836526/
https://www.ncbi.nlm.nih.gov/pubmed/33518776
http://dx.doi.org/10.1016/j.cplett.2020.137935
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author Li, Zhuo
Hirst, Jonathan D.
author_facet Li, Zhuo
Hirst, Jonathan D.
author_sort Li, Zhuo
collection PubMed
description Treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19, may well be predicated on knowledge of the structures of protein of this virus. However, often these cannot be determined easily or quickly. Herein, we provide calculated circular dichroism (CD) spectra in the far- and near-UV, and infra-red (IR) spectra in the amide I region for experimental structures and computational models of SARS-CoV-2 proteins. The near-UV CD spectra offer greatest sensitivity in assessing the accuracy of models.
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spelling pubmed-78365262021-01-26 Computed optical spectra of SARS-CoV-2 proteins() Li, Zhuo Hirst, Jonathan D. Chem Phys Lett Research Paper Treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Covid-19, may well be predicated on knowledge of the structures of protein of this virus. However, often these cannot be determined easily or quickly. Herein, we provide calculated circular dichroism (CD) spectra in the far- and near-UV, and infra-red (IR) spectra in the amide I region for experimental structures and computational models of SARS-CoV-2 proteins. The near-UV CD spectra offer greatest sensitivity in assessing the accuracy of models. Elsevier B.V. 2020-11 2020-08-29 /pmc/articles/PMC7836526/ /pubmed/33518776 http://dx.doi.org/10.1016/j.cplett.2020.137935 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Research Paper
Li, Zhuo
Hirst, Jonathan D.
Computed optical spectra of SARS-CoV-2 proteins()
title Computed optical spectra of SARS-CoV-2 proteins()
title_full Computed optical spectra of SARS-CoV-2 proteins()
title_fullStr Computed optical spectra of SARS-CoV-2 proteins()
title_full_unstemmed Computed optical spectra of SARS-CoV-2 proteins()
title_short Computed optical spectra of SARS-CoV-2 proteins()
title_sort computed optical spectra of sars-cov-2 proteins()
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836526/
https://www.ncbi.nlm.nih.gov/pubmed/33518776
http://dx.doi.org/10.1016/j.cplett.2020.137935
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