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Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes
Sex differences in morbidity and mortality have been reported in the cystic fibrosis (CF) population worldwide. However, it is unclear why CF women have worse clinical outcomes than men. In this review, we focus on the influence of female sex hormones on CF pulmonary outcomes and summarise data from...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836644/ https://www.ncbi.nlm.nih.gov/pubmed/33532475 http://dx.doi.org/10.1183/23120541.00475-2020 |
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author | Lam, Grace Y. Goodwin, Jodi Wilcox, Pearce G. Quon, Bradley S. |
author_facet | Lam, Grace Y. Goodwin, Jodi Wilcox, Pearce G. Quon, Bradley S. |
author_sort | Lam, Grace Y. |
collection | PubMed |
description | Sex differences in morbidity and mortality have been reported in the cystic fibrosis (CF) population worldwide. However, it is unclear why CF women have worse clinical outcomes than men. In this review, we focus on the influence of female sex hormones on CF pulmonary outcomes and summarise data from in vitro and in vivo experiments on how oestrogen and progesterone might modify mucociliary clearance, immunity and infection in the CF airways. The potential for novel sex hormone-related therapeutic interventions is also discussed. |
format | Online Article Text |
id | pubmed-7836644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-78366442021-02-01 Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes Lam, Grace Y. Goodwin, Jodi Wilcox, Pearce G. Quon, Bradley S. ERJ Open Res Reviews Sex differences in morbidity and mortality have been reported in the cystic fibrosis (CF) population worldwide. However, it is unclear why CF women have worse clinical outcomes than men. In this review, we focus on the influence of female sex hormones on CF pulmonary outcomes and summarise data from in vitro and in vivo experiments on how oestrogen and progesterone might modify mucociliary clearance, immunity and infection in the CF airways. The potential for novel sex hormone-related therapeutic interventions is also discussed. European Respiratory Society 2021-01-18 /pmc/articles/PMC7836644/ /pubmed/33532475 http://dx.doi.org/10.1183/23120541.00475-2020 Text en Copyright ©ERS 2021 http://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
spellingShingle | Reviews Lam, Grace Y. Goodwin, Jodi Wilcox, Pearce G. Quon, Bradley S. Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes |
title | Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes |
title_full | Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes |
title_fullStr | Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes |
title_full_unstemmed | Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes |
title_short | Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes |
title_sort | sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836644/ https://www.ncbi.nlm.nih.gov/pubmed/33532475 http://dx.doi.org/10.1183/23120541.00475-2020 |
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