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Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes

Sex differences in morbidity and mortality have been reported in the cystic fibrosis (CF) population worldwide. However, it is unclear why CF women have worse clinical outcomes than men. In this review, we focus on the influence of female sex hormones on CF pulmonary outcomes and summarise data from...

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Detalles Bibliográficos
Autores principales: Lam, Grace Y., Goodwin, Jodi, Wilcox, Pearce G., Quon, Bradley S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836644/
https://www.ncbi.nlm.nih.gov/pubmed/33532475
http://dx.doi.org/10.1183/23120541.00475-2020
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author Lam, Grace Y.
Goodwin, Jodi
Wilcox, Pearce G.
Quon, Bradley S.
author_facet Lam, Grace Y.
Goodwin, Jodi
Wilcox, Pearce G.
Quon, Bradley S.
author_sort Lam, Grace Y.
collection PubMed
description Sex differences in morbidity and mortality have been reported in the cystic fibrosis (CF) population worldwide. However, it is unclear why CF women have worse clinical outcomes than men. In this review, we focus on the influence of female sex hormones on CF pulmonary outcomes and summarise data from in vitro and in vivo experiments on how oestrogen and progesterone might modify mucociliary clearance, immunity and infection in the CF airways. The potential for novel sex hormone-related therapeutic interventions is also discussed.
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spelling pubmed-78366442021-02-01 Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes Lam, Grace Y. Goodwin, Jodi Wilcox, Pearce G. Quon, Bradley S. ERJ Open Res Reviews Sex differences in morbidity and mortality have been reported in the cystic fibrosis (CF) population worldwide. However, it is unclear why CF women have worse clinical outcomes than men. In this review, we focus on the influence of female sex hormones on CF pulmonary outcomes and summarise data from in vitro and in vivo experiments on how oestrogen and progesterone might modify mucociliary clearance, immunity and infection in the CF airways. The potential for novel sex hormone-related therapeutic interventions is also discussed. European Respiratory Society 2021-01-18 /pmc/articles/PMC7836644/ /pubmed/33532475 http://dx.doi.org/10.1183/23120541.00475-2020 Text en Copyright ©ERS 2021 http://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Reviews
Lam, Grace Y.
Goodwin, Jodi
Wilcox, Pearce G.
Quon, Bradley S.
Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes
title Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes
title_full Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes
title_fullStr Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes
title_full_unstemmed Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes
title_short Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes
title_sort sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836644/
https://www.ncbi.nlm.nih.gov/pubmed/33532475
http://dx.doi.org/10.1183/23120541.00475-2020
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