Evolution patterns of SARS-CoV-2: Snapshot on its genome variants

An acute respiratory syndrome (COVID-19), caused by a novel coronavirus (SARS-CoV-2) with a high rate of morbidity and elevate mortality, has emerged as one of the most important threats to humankind in the last centuries. Rigorous determination of SARS-CoV-2 infectivity is very difficult owing to t...

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Detalles Bibliográficos
Autores principales: Giovanetti, Marta, Benedetti, Francesca, Campisi, Giovanni, Ciccozzi, Alessandra, Fabris, Silvia, Ceccarelli, Giancarlo, Tambone, Vittoradolfo, Caruso, Arnaldo, Angeletti, Silvia, Zella, Davide, Ciccozzi, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836704/
https://www.ncbi.nlm.nih.gov/pubmed/33199021
http://dx.doi.org/10.1016/j.bbrc.2020.10.102
Descripción
Sumario:An acute respiratory syndrome (COVID-19), caused by a novel coronavirus (SARS-CoV-2) with a high rate of morbidity and elevate mortality, has emerged as one of the most important threats to humankind in the last centuries. Rigorous determination of SARS-CoV-2 infectivity is very difficult owing to the continuous evolution of the virus, with its single nucleotide polymorphism (SNP) variants and many lineages. However, it is urgently necessary to study the virus in depth, to understand the mechanism of its pathogenicity and virulence, and to develop effective therapeutic strategies. The present contribution summarizes in a succinct way the current knowledge on the evolutionary and structural features of the virus, with the aim of clarifying its mutational pattern and its possible role in the ongoing pandemic.

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