Cargando…

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection carries a substantial risk of severe and prolonged illness; treatment options are currently limited. We assessed the efficacy and safety of inhaled nebulised interferon beta-1a (SNG001) for the treatment of patients a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Monk, Phillip D, Marsden, Richard J, Tear, Victoria J, Brookes, Jody, Batten, Toby N, Mankowski, Marcin, Gabbay, Felicity J, Davies, Donna E, Holgate, Stephen T, Ho, Ling-Pei, Clark, Tristan, Djukanovic, Ratko, Wilkinson, Tom M A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836724/ https://www.ncbi.nlm.nih.gov/pubmed/33189161 http://dx.doi.org/10.1016/S2213-2600(20)30511-7

Ejemplares similares

Nebulised interferon-β1a (SNG001) in hospitalised COVID-19: SPRINTER phase III study
por: Monk, Phillip D., et al.
Publicado: (2023)

375. The Effect of Inhaled Interferon Beta-1a (SNG001) Treatment Compared to Placebo on Lung Antiviral Biomarkers and Viral Clearance in Chronic Obstructive Pulmonary Disease (COPD) Patients With Respiratory Virus Infections
por: Monk, Phillip D, et al.
Publicado: (2023)

Safety and efficacy of inhaled interferon-β1a (SNG001) in adults with mild-to-moderate COVID-19: a randomized, controlled, phase II trial
por: Jagannathan, Prasanna, et al.
Publicado: (2023)

Zanamivir should be inhaled, not nebulised
por: Eagel, Barry A
Publicado: (2010)

Introduction to SNG and ENG microwave
por: Higgins, Jonathan
Publicado: (2004)

The stability and robustness analysis of SNG and PNG supply
por: Zhu, Jianhua, et al.
Publicado: (2020)

Metabolomic and proteomic characterization of sng and pain phenotypes in fibromyalgia
por: Hsu, Wei‐Hsiang, et al.
Publicado: (2021)

SNG and DNG meta-absorber with fractional absorption band for sensing application
por: Hoque, Ahasanul, et al.
Publicado: (2020)

Inhaled nebulised unfractionated heparin (UFH) for the treatment of hospitalised patients with COVID-19: A randomised controlled pilot study()
por: DeNucci, Gilberto, et al.
Publicado: (2023)

Double Nebulisation for Airway Anaesthesia
por: Chugh, Vanya, et al.
Publicado: (2020)

Nebulised surfactant for the treatment of severe COVID-19 in adults (COV-Surf): A structured summary of a study protocol for a randomized controlled trial
por: Dushianthan, Ahilanandan, et al.
Publicado: (2020)

A novel anticancer agent SNG1153 inhibits growth of lung cancer stem/progenitor cells
por: Liu, Shiyang, et al.
Publicado: (2016)

Effects of Sex Steroids and Growth Factors on Migration and Invasion of Endoraetrial Adenocarcinoma SNG‐M Cells in vitro
por: Ueda, Masatsugu, et al.
Publicado: (1996)

Synthesis and characterization of Mg–Zn ferrite based flexible microwave composites and its application as SNG metamaterial
por: Rahman, Md Atiqur, et al.
Publicado: (2021)

Advancing Understanding of Mechanisms of Severe Asthma and Drug Effects Using Transcriptomics
por: Djukanović, Ratko
Publicado: (2019)

Soreness or sng: a common symptom with differential clinical impact from pain in degenerative lumbar spine diseases
por: Chiu, Hsiao-Yean, et al.
Publicado: (2023)

Nebulisers as a potential source of airborne virus
por: Tang, Julian W., et al.
Publicado: (2020)

P141 Has the COVID-19 pandemic affected medication adherence to inhaled nebulised therapy for patients at a large adult cystic fibrosis centre?
por: Iqbal, N., et al.
Publicado: (2021)

Nebulised heparin for patients on ventilation: implications for COVID-19 pneumonia
por: Ball, Lorenzo, et al.
Publicado: (2021)

Nebulisation of Receptor-Targeted Nanocomplexes for Gene Delivery to the Airway Epithelium
por: Manunta, Maria D. I., et al.
Publicado: (2011)

Nebulisation of IVT mRNA Complexes for Intrapulmonary Administration
por: Johler, Sarah M., et al.
Publicado: (2015)

Nebuliser hygiene in cystic fibrosis: evidence-based recommendations
por: Bell, Jane, et al.
Publicado: (2020)

Exploratory study of the effectiveness of nebulised saline in children with neurodisability
por: Galaz Souza, Natalia, et al.
Publicado: (2021)

Randomised controlled trial of nebulised gentamicin in children with bronchiectasis
por: Twiss, Jacob, et al.
Publicado: (2022)

A phase 1 trial of nebulised heparin in acute lung injury
por: Dixon, Barry, et al.
Publicado: (2008)

Dexmedetomidine nebulisation attenuates post-operative sore throat in patients undergoing thyroidectomy: A randomised, double-blind, comparative study with nebulised ketamine
por: Thomas, Derlin, et al.
Publicado: (2020)

Patients’ practices and experiences of using nebuliser therapy in the management of COPD at home
por: Alhaddad, B, et al.
Publicado: (2015)

Phase II studies of nebulised Arikace in CF patients with Pseudomonas aeruginosa infection
por: Clancy, J P, et al.
Publicado: (2013)

Investigation of the Quantity of Exhaled Aerosols Released into the Environment during Nebulisation
por: McGrath, James A., et al.
Publicado: (2019)

COPD: Will There Be Room for Nebulisers After the Current COVID-19 Pandemic?
por: Araújo, António Duarte de, et al.
Publicado: (2020)

Nebulised interferon beta-1a for patients with COVID-19
por: Peiffer-Smadja, Nathan, et al.
Publicado: (2021)

Nebulised Isotonic Hydroxychloroquine Aerosols for Potential Treatment of COVID-19
por: Tai, Waiting, et al.
Publicado: (2021)

Microbial contamination of domiciliary nebulisers and clinical implications in chronic obstructive pulmonary disease
por: Jarvis, S, et al.
Publicado: (2014)

Development of an intervention to increase adherence to nebuliser treatment in adults with cystic fibrosis: CFHealthHub
por: Arden, M. A., et al.
Publicado: (2021)

Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence
por: van Haren, Frank M. P., et al.
Publicado: (2020)

An online survey of Australian physicians reported practice with the off-label use of nebulised frusemide
por: Newton, Phillip J, et al.
Publicado: (2012)

The use of an alternate side lying positioning strategy during inhalation therapy does not prolong nebulisation time in adults with Cystic Fibrosis: a randomised crossover trial
por: Dentice, Ruth L., et al.
Publicado: (2018)

Nebulised heparin: a new approach to the treatment of acute lung injury?
por: Suter, Peter M
Publicado: (2008)

Vibrating Mesh Nebulisation of Pro-Antimicrobial Peptides for Use in Cystic Fibrosis
por: Forde, Éanna, et al.
Publicado: (2019)

Improvement of Pulmonary Photodynamic Therapy: Nebulisation of Curcumin-Loaded Tetraether Liposomes
por: Lehmann, Jennifer, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hi6dfgissuj7hmst3rp4nsj3do