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Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study

BACKGROUND: Numerous studies have concentrated on high-dose radiation exposed accidentally or through therapy, and few involve low-dose occupational exposure, to investigate the correlation between low-dose ionizing radiation and changing hematological parameters among medical workers. METHODS: Usin...

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Autores principales: Liu, Ning, Peng, Yang, Zhong, Xinguang, Ma, Zheng, He, Suiping, Li, Ying, Zhang, Wencui, Gong, Zijun, Yao, Zhenjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836727/
https://www.ncbi.nlm.nih.gov/pubmed/33494698
http://dx.doi.org/10.1186/s12199-021-00939-z
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author Liu, Ning
Peng, Yang
Zhong, Xinguang
Ma, Zheng
He, Suiping
Li, Ying
Zhang, Wencui
Gong, Zijun
Yao, Zhenjiang
author_facet Liu, Ning
Peng, Yang
Zhong, Xinguang
Ma, Zheng
He, Suiping
Li, Ying
Zhang, Wencui
Gong, Zijun
Yao, Zhenjiang
author_sort Liu, Ning
collection PubMed
description BACKGROUND: Numerous studies have concentrated on high-dose radiation exposed accidentally or through therapy, and few involve low-dose occupational exposure, to investigate the correlation between low-dose ionizing radiation and changing hematological parameters among medical workers. METHODS: Using a prospective cohort study design, we collected health examination reports and personal dose monitoring data from medical workers and used Poisson regression and restricted cubic spline models to assess the correlation between changing hematological parameters and cumulative radiation dose and determine the dose-response relationship. RESULTS: We observed that changing platelet of 1265 medical workers followed up was statistically different among the cumulative dose groups (P = 0.010). Although the linear trend tested was not statistically significant (P(trend) = 0.258), the non-linear trend tested was statistically significant (P(non-linear) = 0.007). Overall, there was a correlation between changing platelets and cumulative radiation dose (a change of β(a) 0.008 × 10(9)/L during biennially after adjusting for gender, age at baseline, service at baseline, occupation, medical level, and smoking habits; 95% confidence interval [CI] = 0.003,0.014 × 10(9)/L). Moreover, we also found positive first and then negative dose-response relationships between cumulative radiation dose and changing platelets by restricted cubic spline models, while there were negative patterns of the baseline service not less than 10 years (− 0.015 × 10(9)/L, 95% CI = − 0.024, − 0.007 × 10(9)/L) and radiation nurses(− 0.033 × 10(9)/L, 95% CI = − 0.049, − 0.016 × 10(9)/L). CONCLUSION: We concluded that although the exposure dose was below the limit, medical workers exposed to low-dose ionizing radiation for a short period of time might have increased first and then decreased platelets, and there was a dose-response relationship between the cumulative radiation dose and platelets changing.
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spelling pubmed-78367272021-01-27 Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study Liu, Ning Peng, Yang Zhong, Xinguang Ma, Zheng He, Suiping Li, Ying Zhang, Wencui Gong, Zijun Yao, Zhenjiang Environ Health Prev Med Research Article BACKGROUND: Numerous studies have concentrated on high-dose radiation exposed accidentally or through therapy, and few involve low-dose occupational exposure, to investigate the correlation between low-dose ionizing radiation and changing hematological parameters among medical workers. METHODS: Using a prospective cohort study design, we collected health examination reports and personal dose monitoring data from medical workers and used Poisson regression and restricted cubic spline models to assess the correlation between changing hematological parameters and cumulative radiation dose and determine the dose-response relationship. RESULTS: We observed that changing platelet of 1265 medical workers followed up was statistically different among the cumulative dose groups (P = 0.010). Although the linear trend tested was not statistically significant (P(trend) = 0.258), the non-linear trend tested was statistically significant (P(non-linear) = 0.007). Overall, there was a correlation between changing platelets and cumulative radiation dose (a change of β(a) 0.008 × 10(9)/L during biennially after adjusting for gender, age at baseline, service at baseline, occupation, medical level, and smoking habits; 95% confidence interval [CI] = 0.003,0.014 × 10(9)/L). Moreover, we also found positive first and then negative dose-response relationships between cumulative radiation dose and changing platelets by restricted cubic spline models, while there were negative patterns of the baseline service not less than 10 years (− 0.015 × 10(9)/L, 95% CI = − 0.024, − 0.007 × 10(9)/L) and radiation nurses(− 0.033 × 10(9)/L, 95% CI = − 0.049, − 0.016 × 10(9)/L). CONCLUSION: We concluded that although the exposure dose was below the limit, medical workers exposed to low-dose ionizing radiation for a short period of time might have increased first and then decreased platelets, and there was a dose-response relationship between the cumulative radiation dose and platelets changing. BioMed Central 2021-01-25 2021 /pmc/articles/PMC7836727/ /pubmed/33494698 http://dx.doi.org/10.1186/s12199-021-00939-z Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Liu, Ning
Peng, Yang
Zhong, Xinguang
Ma, Zheng
He, Suiping
Li, Ying
Zhang, Wencui
Gong, Zijun
Yao, Zhenjiang
Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study
title Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study
title_full Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study
title_fullStr Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study
title_full_unstemmed Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study
title_short Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study
title_sort effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836727/
https://www.ncbi.nlm.nih.gov/pubmed/33494698
http://dx.doi.org/10.1186/s12199-021-00939-z
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