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Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study
BACKGROUND: Numerous studies have concentrated on high-dose radiation exposed accidentally or through therapy, and few involve low-dose occupational exposure, to investigate the correlation between low-dose ionizing radiation and changing hematological parameters among medical workers. METHODS: Usin...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836727/ https://www.ncbi.nlm.nih.gov/pubmed/33494698 http://dx.doi.org/10.1186/s12199-021-00939-z |
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author | Liu, Ning Peng, Yang Zhong, Xinguang Ma, Zheng He, Suiping Li, Ying Zhang, Wencui Gong, Zijun Yao, Zhenjiang |
author_facet | Liu, Ning Peng, Yang Zhong, Xinguang Ma, Zheng He, Suiping Li, Ying Zhang, Wencui Gong, Zijun Yao, Zhenjiang |
author_sort | Liu, Ning |
collection | PubMed |
description | BACKGROUND: Numerous studies have concentrated on high-dose radiation exposed accidentally or through therapy, and few involve low-dose occupational exposure, to investigate the correlation between low-dose ionizing radiation and changing hematological parameters among medical workers. METHODS: Using a prospective cohort study design, we collected health examination reports and personal dose monitoring data from medical workers and used Poisson regression and restricted cubic spline models to assess the correlation between changing hematological parameters and cumulative radiation dose and determine the dose-response relationship. RESULTS: We observed that changing platelet of 1265 medical workers followed up was statistically different among the cumulative dose groups (P = 0.010). Although the linear trend tested was not statistically significant (P(trend) = 0.258), the non-linear trend tested was statistically significant (P(non-linear) = 0.007). Overall, there was a correlation between changing platelets and cumulative radiation dose (a change of β(a) 0.008 × 10(9)/L during biennially after adjusting for gender, age at baseline, service at baseline, occupation, medical level, and smoking habits; 95% confidence interval [CI] = 0.003,0.014 × 10(9)/L). Moreover, we also found positive first and then negative dose-response relationships between cumulative radiation dose and changing platelets by restricted cubic spline models, while there were negative patterns of the baseline service not less than 10 years (− 0.015 × 10(9)/L, 95% CI = − 0.024, − 0.007 × 10(9)/L) and radiation nurses(− 0.033 × 10(9)/L, 95% CI = − 0.049, − 0.016 × 10(9)/L). CONCLUSION: We concluded that although the exposure dose was below the limit, medical workers exposed to low-dose ionizing radiation for a short period of time might have increased first and then decreased platelets, and there was a dose-response relationship between the cumulative radiation dose and platelets changing. |
format | Online Article Text |
id | pubmed-7836727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-78367272021-01-27 Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study Liu, Ning Peng, Yang Zhong, Xinguang Ma, Zheng He, Suiping Li, Ying Zhang, Wencui Gong, Zijun Yao, Zhenjiang Environ Health Prev Med Research Article BACKGROUND: Numerous studies have concentrated on high-dose radiation exposed accidentally or through therapy, and few involve low-dose occupational exposure, to investigate the correlation between low-dose ionizing radiation and changing hematological parameters among medical workers. METHODS: Using a prospective cohort study design, we collected health examination reports and personal dose monitoring data from medical workers and used Poisson regression and restricted cubic spline models to assess the correlation between changing hematological parameters and cumulative radiation dose and determine the dose-response relationship. RESULTS: We observed that changing platelet of 1265 medical workers followed up was statistically different among the cumulative dose groups (P = 0.010). Although the linear trend tested was not statistically significant (P(trend) = 0.258), the non-linear trend tested was statistically significant (P(non-linear) = 0.007). Overall, there was a correlation between changing platelets and cumulative radiation dose (a change of β(a) 0.008 × 10(9)/L during biennially after adjusting for gender, age at baseline, service at baseline, occupation, medical level, and smoking habits; 95% confidence interval [CI] = 0.003,0.014 × 10(9)/L). Moreover, we also found positive first and then negative dose-response relationships between cumulative radiation dose and changing platelets by restricted cubic spline models, while there were negative patterns of the baseline service not less than 10 years (− 0.015 × 10(9)/L, 95% CI = − 0.024, − 0.007 × 10(9)/L) and radiation nurses(− 0.033 × 10(9)/L, 95% CI = − 0.049, − 0.016 × 10(9)/L). CONCLUSION: We concluded that although the exposure dose was below the limit, medical workers exposed to low-dose ionizing radiation for a short period of time might have increased first and then decreased platelets, and there was a dose-response relationship between the cumulative radiation dose and platelets changing. BioMed Central 2021-01-25 2021 /pmc/articles/PMC7836727/ /pubmed/33494698 http://dx.doi.org/10.1186/s12199-021-00939-z Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Liu, Ning Peng, Yang Zhong, Xinguang Ma, Zheng He, Suiping Li, Ying Zhang, Wencui Gong, Zijun Yao, Zhenjiang Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study |
title | Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study |
title_full | Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study |
title_fullStr | Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study |
title_full_unstemmed | Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study |
title_short | Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study |
title_sort | effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836727/ https://www.ncbi.nlm.nih.gov/pubmed/33494698 http://dx.doi.org/10.1186/s12199-021-00939-z |
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