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A multidisciplinary registry of patients with autoimmune and immune-mediated diseases with symptomatic COVID-19 from a single center

BACKGROUND AND AIM: There is increasing interest regarding SARS-CoV-2 infection in patients with autoimmune and immune-mediated inflammatory diseases (AI/IMID) with some discrepancies in different cohorts about their risk and outcomes. The aim was to describe a multidisciplinary cohort of patients w...

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Autores principales: Sarmiento-Monroy, Juan C., Espinosa, Gerard, Londoño, Maria-Carlota, Meira, Fernanda, Caballol, Berta, Llufriu, Sara, Carrasco, Josep Lluis, Moll-Udina, Aina, Quintana, Luis F., Giavedoni, Priscila, Ramírez, Julio, Inciarte-Mundo, Jose, Solana, Elisabeth, Blanco, Yolanda, Martinez-Hernandez, Eugenia, Sepúlveda, Maria, Llorenç, Victor, Prieto-González, Sergio, Espígol-Frigolé, Georgina, Milisenda, Jose C., Cid, Maria C., Mascaró, Jose M., Blanco, Isabel, Barberá, Joan Albert, Sibila, Oriol, Gratacos-Ginès, Jordi, Adán, Alfredo, Agustí, Alvaro, Sanmartí, Raimon, Panés, Julian, Cervera, Ricard, Vila, Jordi, Soriano, Alex, Gómez-Puerta, José A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836738/
https://www.ncbi.nlm.nih.gov/pubmed/33338707
http://dx.doi.org/10.1016/j.jaut.2020.102580
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author Sarmiento-Monroy, Juan C.
Espinosa, Gerard
Londoño, Maria-Carlota
Meira, Fernanda
Caballol, Berta
Llufriu, Sara
Carrasco, Josep Lluis
Moll-Udina, Aina
Quintana, Luis F.
Giavedoni, Priscila
Ramírez, Julio
Inciarte-Mundo, Jose
Solana, Elisabeth
Blanco, Yolanda
Martinez-Hernandez, Eugenia
Sepúlveda, Maria
Llorenç, Victor
Prieto-González, Sergio
Espígol-Frigolé, Georgina
Milisenda, Jose C.
Cid, Maria C.
Mascaró, Jose M.
Blanco, Isabel
Barberá, Joan Albert
Sibila, Oriol
Gratacos-Ginès, Jordi
Adán, Alfredo
Agustí, Alvaro
Sanmartí, Raimon
Panés, Julian
Cervera, Ricard
Vila, Jordi
Soriano, Alex
Gómez-Puerta, José A.
author_facet Sarmiento-Monroy, Juan C.
Espinosa, Gerard
Londoño, Maria-Carlota
Meira, Fernanda
Caballol, Berta
Llufriu, Sara
Carrasco, Josep Lluis
Moll-Udina, Aina
Quintana, Luis F.
Giavedoni, Priscila
Ramírez, Julio
Inciarte-Mundo, Jose
Solana, Elisabeth
Blanco, Yolanda
Martinez-Hernandez, Eugenia
Sepúlveda, Maria
Llorenç, Victor
Prieto-González, Sergio
Espígol-Frigolé, Georgina
Milisenda, Jose C.
Cid, Maria C.
Mascaró, Jose M.
Blanco, Isabel
Barberá, Joan Albert
Sibila, Oriol
Gratacos-Ginès, Jordi
Adán, Alfredo
Agustí, Alvaro
Sanmartí, Raimon
Panés, Julian
Cervera, Ricard
Vila, Jordi
Soriano, Alex
Gómez-Puerta, José A.
author_sort Sarmiento-Monroy, Juan C.
collection PubMed
description BACKGROUND AND AIM: There is increasing interest regarding SARS-CoV-2 infection in patients with autoimmune and immune-mediated inflammatory diseases (AI/IMID) with some discrepancies in different cohorts about their risk and outcomes. The aim was to describe a multidisciplinary cohort of patients with AI/IMID and symptomatic SARS-CoV-2 infection in a single tertiary center and analyze sociodemographic, clinical, and therapeutic factors associated with poor outcomes. METHODS: A retrospective observational study was conducted from the 1st of March until May 29th, 2020 in a University tertiary hospital in Barcelona, Spain. Patients with an underlying AI/IMID and symptomatic SARS-CoV-2 infection were identified in our local SARS-CoV-2 infection database. Controls (2:1) were selected from the same database and matched by age and gender. The primary outcome was severe SARS-CoV-2 infection, which was a composite endpoint including admission to the intensive care unit (ICU), need for mechanical ventilation (MV), and/or death. Several covariates including age, sex, and comorbidities among others were combined into a multivariate model having severe SARS-CoV-2 as the dependent variable. Also, a sensitivity analysis was performed evaluating AID and IMID separately. RESULTS: The prevalence of symptomatic SARS-CoV-2 infection in a cohort of AI/IMID patients was 1.3%. Eighty-five patients with AI/IMID and symptomatic SARS-CoV-2 were identified, requiring hospitalization in 58 (68%) cases. A total of 175 patients admitted for SARS-CoV-2 (58 with AI/IMID and 117 matched-controls) were analyzed. In logistic regression analysis, a significant inverse association between AI/IMID group and severe SARS-CoV-2 (OR 0.28; 95% CI 0.12–0.61; p = 0.001), need of MV (OR 0.20; IC 95% 0.05–0.71; p = 0.014), and ICU admission (OR 0.25; IC 95% 0.10–0.62; p = 0.003) was found. CONCLUSIONS: Patients with AI/IMID who require admission for SARS-CoV-2 infection have a lower risk of developing severe disease, including the need to stay in the ICU and MV.
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spelling pubmed-78367382021-01-26 A multidisciplinary registry of patients with autoimmune and immune-mediated diseases with symptomatic COVID-19 from a single center Sarmiento-Monroy, Juan C. Espinosa, Gerard Londoño, Maria-Carlota Meira, Fernanda Caballol, Berta Llufriu, Sara Carrasco, Josep Lluis Moll-Udina, Aina Quintana, Luis F. Giavedoni, Priscila Ramírez, Julio Inciarte-Mundo, Jose Solana, Elisabeth Blanco, Yolanda Martinez-Hernandez, Eugenia Sepúlveda, Maria Llorenç, Victor Prieto-González, Sergio Espígol-Frigolé, Georgina Milisenda, Jose C. Cid, Maria C. Mascaró, Jose M. Blanco, Isabel Barberá, Joan Albert Sibila, Oriol Gratacos-Ginès, Jordi Adán, Alfredo Agustí, Alvaro Sanmartí, Raimon Panés, Julian Cervera, Ricard Vila, Jordi Soriano, Alex Gómez-Puerta, José A. J Autoimmun Article BACKGROUND AND AIM: There is increasing interest regarding SARS-CoV-2 infection in patients with autoimmune and immune-mediated inflammatory diseases (AI/IMID) with some discrepancies in different cohorts about their risk and outcomes. The aim was to describe a multidisciplinary cohort of patients with AI/IMID and symptomatic SARS-CoV-2 infection in a single tertiary center and analyze sociodemographic, clinical, and therapeutic factors associated with poor outcomes. METHODS: A retrospective observational study was conducted from the 1st of March until May 29th, 2020 in a University tertiary hospital in Barcelona, Spain. Patients with an underlying AI/IMID and symptomatic SARS-CoV-2 infection were identified in our local SARS-CoV-2 infection database. Controls (2:1) were selected from the same database and matched by age and gender. The primary outcome was severe SARS-CoV-2 infection, which was a composite endpoint including admission to the intensive care unit (ICU), need for mechanical ventilation (MV), and/or death. Several covariates including age, sex, and comorbidities among others were combined into a multivariate model having severe SARS-CoV-2 as the dependent variable. Also, a sensitivity analysis was performed evaluating AID and IMID separately. RESULTS: The prevalence of symptomatic SARS-CoV-2 infection in a cohort of AI/IMID patients was 1.3%. Eighty-five patients with AI/IMID and symptomatic SARS-CoV-2 were identified, requiring hospitalization in 58 (68%) cases. A total of 175 patients admitted for SARS-CoV-2 (58 with AI/IMID and 117 matched-controls) were analyzed. In logistic regression analysis, a significant inverse association between AI/IMID group and severe SARS-CoV-2 (OR 0.28; 95% CI 0.12–0.61; p = 0.001), need of MV (OR 0.20; IC 95% 0.05–0.71; p = 0.014), and ICU admission (OR 0.25; IC 95% 0.10–0.62; p = 0.003) was found. CONCLUSIONS: Patients with AI/IMID who require admission for SARS-CoV-2 infection have a lower risk of developing severe disease, including the need to stay in the ICU and MV. Elsevier Ltd. 2021-02 2020-11-30 /pmc/articles/PMC7836738/ /pubmed/33338707 http://dx.doi.org/10.1016/j.jaut.2020.102580 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Sarmiento-Monroy, Juan C.
Espinosa, Gerard
Londoño, Maria-Carlota
Meira, Fernanda
Caballol, Berta
Llufriu, Sara
Carrasco, Josep Lluis
Moll-Udina, Aina
Quintana, Luis F.
Giavedoni, Priscila
Ramírez, Julio
Inciarte-Mundo, Jose
Solana, Elisabeth
Blanco, Yolanda
Martinez-Hernandez, Eugenia
Sepúlveda, Maria
Llorenç, Victor
Prieto-González, Sergio
Espígol-Frigolé, Georgina
Milisenda, Jose C.
Cid, Maria C.
Mascaró, Jose M.
Blanco, Isabel
Barberá, Joan Albert
Sibila, Oriol
Gratacos-Ginès, Jordi
Adán, Alfredo
Agustí, Alvaro
Sanmartí, Raimon
Panés, Julian
Cervera, Ricard
Vila, Jordi
Soriano, Alex
Gómez-Puerta, José A.
A multidisciplinary registry of patients with autoimmune and immune-mediated diseases with symptomatic COVID-19 from a single center
title A multidisciplinary registry of patients with autoimmune and immune-mediated diseases with symptomatic COVID-19 from a single center
title_full A multidisciplinary registry of patients with autoimmune and immune-mediated diseases with symptomatic COVID-19 from a single center
title_fullStr A multidisciplinary registry of patients with autoimmune and immune-mediated diseases with symptomatic COVID-19 from a single center
title_full_unstemmed A multidisciplinary registry of patients with autoimmune and immune-mediated diseases with symptomatic COVID-19 from a single center
title_short A multidisciplinary registry of patients with autoimmune and immune-mediated diseases with symptomatic COVID-19 from a single center
title_sort multidisciplinary registry of patients with autoimmune and immune-mediated diseases with symptomatic covid-19 from a single center
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836738/
https://www.ncbi.nlm.nih.gov/pubmed/33338707
http://dx.doi.org/10.1016/j.jaut.2020.102580
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