Drug targets, mechanisms of drug action, and therapeutics against SARS-CoV-2

The recent outbreak of COVID-19 has affected human lives severely. The human-to-human transmission of this viral disease has become deadly due to the unavailability of COVID-19 specific drugs. Here, an overview of various attempts made to design different therapeutic agents against various structura...

Descripción completa

Detalles Bibliográficos
Autor principal: Jena, N.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836883/
http://dx.doi.org/10.1016/j.chphi.2021.100011
_version_ 1783642841895927808
author Jena, N.R.
author_facet Jena, N.R.
author_sort Jena, N.R.
collection PubMed
description The recent outbreak of COVID-19 has affected human lives severely. The human-to-human transmission of this viral disease has become deadly due to the unavailability of COVID-19 specific drugs. Here, an overview of various attempts made to design different therapeutic agents against various structural and non-structural proteins of SARS-CoV-2 has been summarized. Emphasis has been made to highlight the mechanisms of drug action and ways to design better inhibitors of these proteins. The roles of anti-oxidants and vitamins in suppressing COVID-19 are also discussed.
format Online
Article
Text
id pubmed-7836883
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Author(s). Published by Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-78368832021-01-26 Drug targets, mechanisms of drug action, and therapeutics against SARS-CoV-2 Jena, N.R. Chemical Physics Impact Article The recent outbreak of COVID-19 has affected human lives severely. The human-to-human transmission of this viral disease has become deadly due to the unavailability of COVID-19 specific drugs. Here, an overview of various attempts made to design different therapeutic agents against various structural and non-structural proteins of SARS-CoV-2 has been summarized. Emphasis has been made to highlight the mechanisms of drug action and ways to design better inhibitors of these proteins. The roles of anti-oxidants and vitamins in suppressing COVID-19 are also discussed. The Author(s). Published by Elsevier B.V. 2021-06 2021-01-12 /pmc/articles/PMC7836883/ http://dx.doi.org/10.1016/j.chphi.2021.100011 Text en © 2021 The Author(s). Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Jena, N.R.
Drug targets, mechanisms of drug action, and therapeutics against SARS-CoV-2
title Drug targets, mechanisms of drug action, and therapeutics against SARS-CoV-2
title_full Drug targets, mechanisms of drug action, and therapeutics against SARS-CoV-2
title_fullStr Drug targets, mechanisms of drug action, and therapeutics against SARS-CoV-2
title_full_unstemmed Drug targets, mechanisms of drug action, and therapeutics against SARS-CoV-2
title_short Drug targets, mechanisms of drug action, and therapeutics against SARS-CoV-2
title_sort drug targets, mechanisms of drug action, and therapeutics against sars-cov-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836883/
http://dx.doi.org/10.1016/j.chphi.2021.100011
work_keys_str_mv AT jenanr drugtargetsmechanismsofdrugactionandtherapeuticsagainstsarscov2

Ejemplares similares