How nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of COVID-19 infection?

Statistical surveys of COVID-19 patients indicate, against all common logic, that people who smoke are less prone to the infection and/or exhibit less severe respiratory symptoms than non-smokers. This suggests that nicotine may have some preventive or modulatory effect on the inflammatory response...

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Autores principales: Kloc, Malgorzata, Ghobrial, Rafik M., Kubiak, Jacek Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Federation of Immunological Societies. Published by Elsevier B.V. 2020
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836994/
https://www.ncbi.nlm.nih.gov/pubmed/32522666
http://dx.doi.org/10.1016/j.imlet.2020.06.002
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author Kloc, Malgorzata
Ghobrial, Rafik M.
Kubiak, Jacek Z
author_facet Kloc, Malgorzata
Ghobrial, Rafik M.
Kubiak, Jacek Z
author_sort Kloc, Malgorzata
collection PubMed
description Statistical surveys of COVID-19 patients indicate, against all common logic, that people who smoke are less prone to the infection and/or exhibit less severe respiratory symptoms than non-smokers. This suggests that nicotine may have some preventive or modulatory effect on the inflammatory response in the lungs. Because it is known that the response to, and resolution of the SARS-CoV-2 infection depends mainly on the lung macrophages, we discuss the recent scientific findings, which may explain why and how nicotine may modulate lung macrophage response during COVID-19 infection.
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spelling pubmed-78369942021-01-26 How nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of COVID-19 infection? Kloc, Malgorzata Ghobrial, Rafik M. Kubiak, Jacek Z Immunol Lett Correspondence Statistical surveys of COVID-19 patients indicate, against all common logic, that people who smoke are less prone to the infection and/or exhibit less severe respiratory symptoms than non-smokers. This suggests that nicotine may have some preventive or modulatory effect on the inflammatory response in the lungs. Because it is known that the response to, and resolution of the SARS-CoV-2 infection depends mainly on the lung macrophages, we discuss the recent scientific findings, which may explain why and how nicotine may modulate lung macrophage response during COVID-19 infection. European Federation of Immunological Societies. Published by Elsevier B.V. 2020-08 2020-06-06 /pmc/articles/PMC7836994/ /pubmed/32522666 http://dx.doi.org/10.1016/j.imlet.2020.06.002 Text en © 2020 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Correspondence
Kloc, Malgorzata
Ghobrial, Rafik M.
Kubiak, Jacek Z
How nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of COVID-19 infection?
title How nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of COVID-19 infection?
title_full How nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of COVID-19 infection?
title_fullStr How nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of COVID-19 infection?
title_full_unstemmed How nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of COVID-19 infection?
title_short How nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of COVID-19 infection?
title_sort how nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of covid-19 infection?
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7836994/
https://www.ncbi.nlm.nih.gov/pubmed/32522666
http://dx.doi.org/10.1016/j.imlet.2020.06.002
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