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Low dose radiation and circulatory diseases: a brief narrative review

Exposure to high doses of ionizing radiation is associated with damage to the heart and coronary arteries. However, only recently have studies with high-quality individual dosimetry data allowed this risk to be estimated while adjusting for concomitant chemotherapy. An association between lower dose...

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Autores principales: Little, Mark P., Lipshultz, Steven E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837141/
https://www.ncbi.nlm.nih.gov/pubmed/33530149
http://dx.doi.org/10.1186/s40959-015-0007-6
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author Little, Mark P.
Lipshultz, Steven E.
author_facet Little, Mark P.
Lipshultz, Steven E.
author_sort Little, Mark P.
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description Exposure to high doses of ionizing radiation is associated with damage to the heart and coronary arteries. However, only recently have studies with high-quality individual dosimetry data allowed this risk to be estimated while adjusting for concomitant chemotherapy. An association between lower dose exposures and late-occurring circulatory disease has only recently been suspected in the Japanese atomic bomb survivors and in various occupationally exposed cohorts and is still controversial. Excess relative risks per unit dose in moderate- and low-dose epidemiological studies are variable, possibly resulting from confounding and effect-modification by well known (but unobserved) risk factors. Here, we summarize the evidence for a causal association between moderate- and low-level radiation exposure (whether at high or low dose rates) and circulatory disease.
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spelling pubmed-78371412021-01-27 Low dose radiation and circulatory diseases: a brief narrative review Little, Mark P. Lipshultz, Steven E. Cardiooncology Review Exposure to high doses of ionizing radiation is associated with damage to the heart and coronary arteries. However, only recently have studies with high-quality individual dosimetry data allowed this risk to be estimated while adjusting for concomitant chemotherapy. An association between lower dose exposures and late-occurring circulatory disease has only recently been suspected in the Japanese atomic bomb survivors and in various occupationally exposed cohorts and is still controversial. Excess relative risks per unit dose in moderate- and low-dose epidemiological studies are variable, possibly resulting from confounding and effect-modification by well known (but unobserved) risk factors. Here, we summarize the evidence for a causal association between moderate- and low-level radiation exposure (whether at high or low dose rates) and circulatory disease. BioMed Central 2015-11-26 /pmc/articles/PMC7837141/ /pubmed/33530149 http://dx.doi.org/10.1186/s40959-015-0007-6 Text en © Little and Lipshultz. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Little, Mark P.
Lipshultz, Steven E.
Low dose radiation and circulatory diseases: a brief narrative review
title Low dose radiation and circulatory diseases: a brief narrative review
title_full Low dose radiation and circulatory diseases: a brief narrative review
title_fullStr Low dose radiation and circulatory diseases: a brief narrative review
title_full_unstemmed Low dose radiation and circulatory diseases: a brief narrative review
title_short Low dose radiation and circulatory diseases: a brief narrative review
title_sort low dose radiation and circulatory diseases: a brief narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837141/
https://www.ncbi.nlm.nih.gov/pubmed/33530149
http://dx.doi.org/10.1186/s40959-015-0007-6
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