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Systematic Activity Maturation of a Single-Domain Antibody with Non-canonical Amino Acids through Chemical Mutagenesis

Great advances have been made over the last four decades in therapeutic and diagnostic applications of antibodies. The activity maturation of antibody candidates, however, remains a significant challenge. To address this problem, we present a method that enables the systematic enhancement of the act...

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Detalles Bibliográficos
Autores principales:	Lindstedt, Philip R., Aprile, Francesco A., Sormanni, Pietro, Rakoto, Robertinah, Dobson, Christopher M., Bernardes, Gonçalo J.L., Vendruscolo, Michele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837213/ https://www.ncbi.nlm.nih.gov/pubmed/33217338 http://dx.doi.org/10.1016/j.chembiol.2020.11.002

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