Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis

While antibiotics are intended to specifically target bacteria, most are known to affect host cell physiology. In addition, some antibiotic classes are reported as immunosuppressive for reasons that remain unclear. Here, we show that Linezolid, a ribosomal-targeting antibiotic (RAbo), effectively bl...

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Detalles Bibliográficos
Autores principales: Almeida, Luís, Dhillon-LaBrooy, Ayesha, Castro, Carla N., Adossa, Nigatu, Carriche, Guilhermina M., Guderian, Melanie, Lippens, Saskia, Dennerlein, Sven, Hesse, Christina, Lambrecht, Bart N., Berod, Luciana, Schauser, Leif, Blazar, Bruce R., Kalesse, Markus, Müller, Rolf, Moita, Luís F., Sparwasser, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837214/
https://www.ncbi.nlm.nih.gov/pubmed/33238133
http://dx.doi.org/10.1016/j.immuni.2020.11.001

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