Cargando…
Reproductive Disorders in Male Rats Induced by High-fructose Consumption from Juvenile Age to Puberty
There is compelling evidence that a hypercaloric, high-fructose diet can cause metabolic syndrome (MetS) and a whole range of other metabolic changes. In the context of androgen deficiency, MetS in boys merits special attention, but the effects of fructose-rich diet in youth on future male reproduct...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sciendo
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837242/ https://www.ncbi.nlm.nih.gov/pubmed/32597133 http://dx.doi.org/10.2478/aiht-2020-71-3303 |
_version_ | 1783642921956802560 |
---|---|
author | Tkachenko, Oleksandr Y. Shayakhmetova, Ganna M. Matvienko, Anatoliy V. Kovalenko, Valentina M. |
author_facet | Tkachenko, Oleksandr Y. Shayakhmetova, Ganna M. Matvienko, Anatoliy V. Kovalenko, Valentina M. |
author_sort | Tkachenko, Oleksandr Y. |
collection | PubMed |
description | There is compelling evidence that a hypercaloric, high-fructose diet can cause metabolic syndrome (MetS) and a whole range of other metabolic changes. In the context of androgen deficiency, MetS in boys merits special attention, but the effects of fructose-rich diet in youth on future male reproductive function are still poorly evidenced. The aim of this study was to address this issue and analyse the effects of high-fructose intake starting from weaning to puberty (postnatal day 23 up to 83) on the reproductive function of male rats. For this purpose juvenile male Wistar rats were divided in two groups: control and the group receiving 10 % fructose solution instead of drinking water. Reproductive function was evaluated in terms of fertility, sperm count, testes/epididymis morphology, and serum sex hormones. The fructose-treated group showed a decrease in testosterone and twofold increase in luteinising and follicle-stimulating hormone levels in the serum. This was accompanied with lower testis/epididymis weights, sperm count, and changed testis/epididymis morphology. Their fertility remained unchanged, but the fertility of females mating with these males diminished. In addition, pre-implantation and post-implantation embryonic death rate rose in these females. Our results have confirmed that high fructose consumption from early age until puberty can impair the reproductive function of male rats, and call for further animal and epidemiological investigation. |
format | Online Article Text |
id | pubmed-7837242 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Sciendo |
record_format | MEDLINE/PubMed |
spelling | pubmed-78372422021-05-25 Reproductive Disorders in Male Rats Induced by High-fructose Consumption from Juvenile Age to Puberty Tkachenko, Oleksandr Y. Shayakhmetova, Ganna M. Matvienko, Anatoliy V. Kovalenko, Valentina M. Arh Hig Rada Toksikol Original Article There is compelling evidence that a hypercaloric, high-fructose diet can cause metabolic syndrome (MetS) and a whole range of other metabolic changes. In the context of androgen deficiency, MetS in boys merits special attention, but the effects of fructose-rich diet in youth on future male reproductive function are still poorly evidenced. The aim of this study was to address this issue and analyse the effects of high-fructose intake starting from weaning to puberty (postnatal day 23 up to 83) on the reproductive function of male rats. For this purpose juvenile male Wistar rats were divided in two groups: control and the group receiving 10 % fructose solution instead of drinking water. Reproductive function was evaluated in terms of fertility, sperm count, testes/epididymis morphology, and serum sex hormones. The fructose-treated group showed a decrease in testosterone and twofold increase in luteinising and follicle-stimulating hormone levels in the serum. This was accompanied with lower testis/epididymis weights, sperm count, and changed testis/epididymis morphology. Their fertility remained unchanged, but the fertility of females mating with these males diminished. In addition, pre-implantation and post-implantation embryonic death rate rose in these females. Our results have confirmed that high fructose consumption from early age until puberty can impair the reproductive function of male rats, and call for further animal and epidemiological investigation. Sciendo 2020-04-09 /pmc/articles/PMC7837242/ /pubmed/32597133 http://dx.doi.org/10.2478/aiht-2020-71-3303 Text en © 2020 Oleksandr Y. Tkachenko, Ganna M. Shayakhmetova, Anatoliy V. Matvienko, Valentina M. Kovalenko, published by Sciendo http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. |
spellingShingle | Original Article Tkachenko, Oleksandr Y. Shayakhmetova, Ganna M. Matvienko, Anatoliy V. Kovalenko, Valentina M. Reproductive Disorders in Male Rats Induced by High-fructose Consumption from Juvenile Age to Puberty |
title | Reproductive Disorders in Male Rats Induced by High-fructose Consumption from Juvenile Age to Puberty |
title_full | Reproductive Disorders in Male Rats Induced by High-fructose Consumption from Juvenile Age to Puberty |
title_fullStr | Reproductive Disorders in Male Rats Induced by High-fructose Consumption from Juvenile Age to Puberty |
title_full_unstemmed | Reproductive Disorders in Male Rats Induced by High-fructose Consumption from Juvenile Age to Puberty |
title_short | Reproductive Disorders in Male Rats Induced by High-fructose Consumption from Juvenile Age to Puberty |
title_sort | reproductive disorders in male rats induced by high-fructose consumption from juvenile age to puberty |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837242/ https://www.ncbi.nlm.nih.gov/pubmed/32597133 http://dx.doi.org/10.2478/aiht-2020-71-3303 |
work_keys_str_mv | AT tkachenkooleksandry reproductivedisordersinmaleratsinducedbyhighfructoseconsumptionfromjuvenileagetopuberty AT shayakhmetovagannam reproductivedisordersinmaleratsinducedbyhighfructoseconsumptionfromjuvenileagetopuberty AT matvienkoanatoliyv reproductivedisordersinmaleratsinducedbyhighfructoseconsumptionfromjuvenileagetopuberty AT kovalenkovalentinam reproductivedisordersinmaleratsinducedbyhighfructoseconsumptionfromjuvenileagetopuberty |