ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

Alzheimer’s disease (AD) risk gene ApoE4 perturbs brain lipid homeostasis and energy transduction. However, the cell-type-specific mechanism of ApoE4 in modulating brain lipid metabolism is unclear. Here, we describe a detrimental role of ApoE4 in regulating fatty acid (FA) metabolism across neuron...

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Detalles Bibliográficos
Autores principales: Qi, Guoyuan, Mi, Yashi, Shi, Xiaojian, Gu, Haiwei, Brinton, Roberta Diaz, Yin, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837265/
https://www.ncbi.nlm.nih.gov/pubmed/33406436
http://dx.doi.org/10.1016/j.celrep.2020.108572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837265/
https://www.ncbi.nlm.nih.gov/pubmed/33406436
http://dx.doi.org/10.1016/j.celrep.2020.108572

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