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Protracted cholera outbreak in the Central Region, Ghana, 2016

OBJECTIVE: On 24th October 2016, the Central Regional Health Directorate received report of a suspected cholera outbreak in the Cape Coast Metropolis (CCM). We investigated to confirm the diagnosis, identify risk factors and implement control measures. DESIGN: We used a descriptive study followed by...

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Autores principales: Issahaku, Gyesi R, Asiedu-Bekoe, Franklin, Kwashie, Samuel, Broni, Francis, Boateng, Paul, Alomatu, Holy, Houphouet, Ekua E, Asante, Afua A, Ameme, Donne K, Kenu, Ernest
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ghana Medical Association 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837350/
https://www.ncbi.nlm.nih.gov/pubmed/33536668
http://dx.doi.org/10.4314/gmj.v54i2s.8
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author Issahaku, Gyesi R
Asiedu-Bekoe, Franklin
Kwashie, Samuel
Broni, Francis
Boateng, Paul
Alomatu, Holy
Houphouet, Ekua E
Asante, Afua A
Ameme, Donne K
Kenu, Ernest
author_facet Issahaku, Gyesi R
Asiedu-Bekoe, Franklin
Kwashie, Samuel
Broni, Francis
Boateng, Paul
Alomatu, Holy
Houphouet, Ekua E
Asante, Afua A
Ameme, Donne K
Kenu, Ernest
author_sort Issahaku, Gyesi R
collection PubMed
description OBJECTIVE: On 24th October 2016, the Central Regional Health Directorate received report of a suspected cholera outbreak in the Cape Coast Metropolis (CCM). We investigated to confirm the diagnosis, identify risk factors and implement control measures. DESIGN: We used a descriptive study followed by 1:2 unmatched case-control study. DATA SOURCE: We reviewed medical records, conducted active case search and contact tracing, interviewed case-patients and their contacts and conducted environmental assessment. Case-patients' stool samples were tested with point of care test kits (SD Bioline Cholera Ag 01/0139) and sent to the Cape Coast Teaching Hospital Laboratory for confirmation. MAIN OUTCOMES: Cause of outbreak, risk factors associated with spread of outbreak RESULTS: Vibrio cholerae serotype Ogawa caused the outbreak. There was no mortality. Of 704 case-patients, 371(52.7%) were males and 55(7.8%) were aged under-five years. The median age was 23 years (interquartile range: 16–32 years). About a third 248(35.2%) of the case patients were aged 15–24 years. The University of Cape Coast subdistrict was the epicenter with 341(48.44%) cases. Compared to controls, cholera case-patients were more likely to have visited Cholera Treatment Centers (CTC) (aOR=12.1, 95%CI: 1.5–101.3), drank pipe-borne water (aOR=11.7, 95%CI: 3.3–41.8), or drank street-vended sachet water (aOR=11.0, 95%CI: 3.7–32.9). Open defecation and broken sewage pipes were observed in the epicenter. CONCLUSION: Vibrio cholerae serotype Ogawa caused the CCM cholera outbreak mostly affecting the youth. Visiting CTC was a major risk factor. Prompt case-management, contact tracing, health education, restricting access to CTC and implementing water sanitation and hygiene activities helped in the control. FUNDING: This work was supported by Ghana Field Epidemiology and Laboratory Training Program (GFELTP), University of Ghana
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spelling pubmed-78373502021-02-02 Protracted cholera outbreak in the Central Region, Ghana, 2016 Issahaku, Gyesi R Asiedu-Bekoe, Franklin Kwashie, Samuel Broni, Francis Boateng, Paul Alomatu, Holy Houphouet, Ekua E Asante, Afua A Ameme, Donne K Kenu, Ernest Ghana Med J Original Article OBJECTIVE: On 24th October 2016, the Central Regional Health Directorate received report of a suspected cholera outbreak in the Cape Coast Metropolis (CCM). We investigated to confirm the diagnosis, identify risk factors and implement control measures. DESIGN: We used a descriptive study followed by 1:2 unmatched case-control study. DATA SOURCE: We reviewed medical records, conducted active case search and contact tracing, interviewed case-patients and their contacts and conducted environmental assessment. Case-patients' stool samples were tested with point of care test kits (SD Bioline Cholera Ag 01/0139) and sent to the Cape Coast Teaching Hospital Laboratory for confirmation. MAIN OUTCOMES: Cause of outbreak, risk factors associated with spread of outbreak RESULTS: Vibrio cholerae serotype Ogawa caused the outbreak. There was no mortality. Of 704 case-patients, 371(52.7%) were males and 55(7.8%) were aged under-five years. The median age was 23 years (interquartile range: 16–32 years). About a third 248(35.2%) of the case patients were aged 15–24 years. The University of Cape Coast subdistrict was the epicenter with 341(48.44%) cases. Compared to controls, cholera case-patients were more likely to have visited Cholera Treatment Centers (CTC) (aOR=12.1, 95%CI: 1.5–101.3), drank pipe-borne water (aOR=11.7, 95%CI: 3.3–41.8), or drank street-vended sachet water (aOR=11.0, 95%CI: 3.7–32.9). Open defecation and broken sewage pipes were observed in the epicenter. CONCLUSION: Vibrio cholerae serotype Ogawa caused the CCM cholera outbreak mostly affecting the youth. Visiting CTC was a major risk factor. Prompt case-management, contact tracing, health education, restricting access to CTC and implementing water sanitation and hygiene activities helped in the control. FUNDING: This work was supported by Ghana Field Epidemiology and Laboratory Training Program (GFELTP), University of Ghana Ghana Medical Association 2020-06 /pmc/articles/PMC7837350/ /pubmed/33536668 http://dx.doi.org/10.4314/gmj.v54i2s.8 Text en Copyright © The Author(s). This is an Open Access article under the CC BY license.
spellingShingle Original Article
Issahaku, Gyesi R
Asiedu-Bekoe, Franklin
Kwashie, Samuel
Broni, Francis
Boateng, Paul
Alomatu, Holy
Houphouet, Ekua E
Asante, Afua A
Ameme, Donne K
Kenu, Ernest
Protracted cholera outbreak in the Central Region, Ghana, 2016
title Protracted cholera outbreak in the Central Region, Ghana, 2016
title_full Protracted cholera outbreak in the Central Region, Ghana, 2016
title_fullStr Protracted cholera outbreak in the Central Region, Ghana, 2016
title_full_unstemmed Protracted cholera outbreak in the Central Region, Ghana, 2016
title_short Protracted cholera outbreak in the Central Region, Ghana, 2016
title_sort protracted cholera outbreak in the central region, ghana, 2016
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837350/
https://www.ncbi.nlm.nih.gov/pubmed/33536668
http://dx.doi.org/10.4314/gmj.v54i2s.8
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