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YY1 and CP2c in Unidirectional Spermatogenesis and Stemness

Spermatogonial stem cells (SSCs) have stemness characteristics, including germ cell-specific imprints that allow them to form gametes. Spermatogenesis involves changes in gene expression such as a transition from expression of somatic to germ cell-specific genes, global repression of gene expression...

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Autores principales: Cheon, Yong-Pil, Choi, Donchan, Lee, Sung-Ho, Kim, Chul Geun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Developmental Biology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837418/
https://www.ncbi.nlm.nih.gov/pubmed/33537512
http://dx.doi.org/10.12717/DR.2020.24.4.249
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author Cheon, Yong-Pil
Choi, Donchan
Lee, Sung-Ho
Kim, Chul Geun
author_facet Cheon, Yong-Pil
Choi, Donchan
Lee, Sung-Ho
Kim, Chul Geun
author_sort Cheon, Yong-Pil
collection PubMed
description Spermatogonial stem cells (SSCs) have stemness characteristics, including germ cell-specific imprints that allow them to form gametes. Spermatogenesis involves changes in gene expression such as a transition from expression of somatic to germ cell-specific genes, global repression of gene expression, meiotic sex chromosome inactivation, highly condensed packing of the nucleus with protamines, and morphogenesis. These step-by-step processes finally generate spermatozoa that are fertilization competent. Dynamic epigenetic modifications also confer totipotency to germ cells after fertilization. Primordial germ cells (PGCs) in embryos do not enter meiosis, remain in the proliferative stage, and are referred to as gonocytes, before entering quiescence. Gonocytes develop into SSCs at about 6 days after birth in rodents. Although chromatin structural modification by Polycomb is essential for gene silencing in mammals, and epigenetic changes are critical in spermatogenesis, a comprehensive understanding of transcriptional regulation is lacking. Recently, we evaluated the expression profiles of Yin Yang 1 (YY1) and CP2c in the gonads of E14.5 and 12-week-old mice. YY1 localizes at the nucleus and/or cytoplasm at specific stages of spermatogenesis, possibly by interaction with CP2c and YY1-interacting transcription factor. In the present article, we discuss the possible roles of YY1 and CP2c in spermatogenesis and stemness based on our results and a review of the relevant literature.
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spelling pubmed-78374182021-02-02 YY1 and CP2c in Unidirectional Spermatogenesis and Stemness Cheon, Yong-Pil Choi, Donchan Lee, Sung-Ho Kim, Chul Geun Dev Reprod Review Spermatogonial stem cells (SSCs) have stemness characteristics, including germ cell-specific imprints that allow them to form gametes. Spermatogenesis involves changes in gene expression such as a transition from expression of somatic to germ cell-specific genes, global repression of gene expression, meiotic sex chromosome inactivation, highly condensed packing of the nucleus with protamines, and morphogenesis. These step-by-step processes finally generate spermatozoa that are fertilization competent. Dynamic epigenetic modifications also confer totipotency to germ cells after fertilization. Primordial germ cells (PGCs) in embryos do not enter meiosis, remain in the proliferative stage, and are referred to as gonocytes, before entering quiescence. Gonocytes develop into SSCs at about 6 days after birth in rodents. Although chromatin structural modification by Polycomb is essential for gene silencing in mammals, and epigenetic changes are critical in spermatogenesis, a comprehensive understanding of transcriptional regulation is lacking. Recently, we evaluated the expression profiles of Yin Yang 1 (YY1) and CP2c in the gonads of E14.5 and 12-week-old mice. YY1 localizes at the nucleus and/or cytoplasm at specific stages of spermatogenesis, possibly by interaction with CP2c and YY1-interacting transcription factor. In the present article, we discuss the possible roles of YY1 and CP2c in spermatogenesis and stemness based on our results and a review of the relevant literature. Korean Society of Developmental Biology 2020-12 2020-12-31 /pmc/articles/PMC7837418/ /pubmed/33537512 http://dx.doi.org/10.12717/DR.2020.24.4.249 Text en © Copyright 2020 The Korean Society of Developmental Biology http://creative-commons.org/licenses/by-nc/3.0/ This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creative-commons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Cheon, Yong-Pil
Choi, Donchan
Lee, Sung-Ho
Kim, Chul Geun
YY1 and CP2c in Unidirectional Spermatogenesis and Stemness
title YY1 and CP2c in Unidirectional Spermatogenesis and Stemness
title_full YY1 and CP2c in Unidirectional Spermatogenesis and Stemness
title_fullStr YY1 and CP2c in Unidirectional Spermatogenesis and Stemness
title_full_unstemmed YY1 and CP2c in Unidirectional Spermatogenesis and Stemness
title_short YY1 and CP2c in Unidirectional Spermatogenesis and Stemness
title_sort yy1 and cp2c in unidirectional spermatogenesis and stemness
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837418/
https://www.ncbi.nlm.nih.gov/pubmed/33537512
http://dx.doi.org/10.12717/DR.2020.24.4.249
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