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Adipocyte-induced transdifferentiation of osteoblasts and its potential role in age-related bone loss

Our preliminary findings have lead us to propose bone marrow adipocyte secretions as new contributors to bone loss. Indeed, using a coculture model based on human bone marrow stromal cells, we previously showed that soluble factors secreted by adipocytes induced the conversion of osteoblasts towards...

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Detalles Bibliográficos
Autores principales: Clabaut, Aline, Grare, Céline, Rolland-Valognes, Gaëlle, Letarouilly, Jean-Guillaume, Bourrier, Chantal, Andersen, Thomas L., Sikjær, Tanja, Rejnmark, Lars, Ejersted, Charlotte, Pastoureau, Philippe, Hardouin, Pierre, Sabatini, Massimo, Broux, Odile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837466/
https://www.ncbi.nlm.nih.gov/pubmed/33497412
http://dx.doi.org/10.1371/journal.pone.0245014